Featured Research

from universities, journals, and other organizations

Can the zebrafish help us to search for new pain drugs?

Date:
September 3, 2013
Source:
Sbarro Health Research Organization (SHRO)
Summary:
Neuropathic pain is caused by injury of the central or peripheral nervous system. Neuropathic pain is difficult to treat because rarely responds to opiates. Studying neuropathic pain in humans has major ethical and experimental limitations. The use of alternate mammalian animal models has been the solution for many years. For both human and animal studies scientists had to rely frequently on behavioral tests that may not directly reflect the experience the animal is going through. Thus, this may be one of the reasons because our ability to treat pain symptoms still relies on a small number of drugs. This suggests that the use of other model systems may help to discovery new compounds with potential analgesic activity.

Neuropathic pain is caused by injury of the central or peripheral nervous system. Neuropathic pain is difficult to treat because rarely responds to opiates. Studying neuropathic pain in humans has major ethical and experimental limitations. The use of alternate mammalian animal models has been the solution for many years. For both human and animal studies scientists had to rely frequently on behavioral tests that may not directly reflect the experience the animal is going through. Thus, this may be one of the reasons because our ability to treat pain symptoms still relies on a small number of drugs. This suggests that the use of other model systems may help to discovery new compounds with potential analgesic activity.

A new published study in Journal of Cellular Physiology by a team led by Dr. Antonio Giordano and Dr. Gianfranco Bellipanni of Sbarro Institute for Cancer Research and Molecular Medicine and Temple University (Philadelphia, USA) adds a new prospective on the research on pain perception. They used larvae of the small vertebrate zebrafish to show that at the molecular level they respond to stimuli that induce inflammation and axons degenerations similarly to mammals.

"We found the highest temperature zebrafish larvae could survive and exposed them for only 5 seconds, the results where similar to human severe skin burns. " Dr. Giordano said. " Then we went to see if the panel of genes, activated by pain in humans, was activated also in the fish. Interestingly, they were activated at the right place and time."

We asked Dr. Gianfranco Bellipanni to explain how this research could have implications for humans: "to understand better the mechanism of neuropathic pain and to discovery new drugs first we need an animal model that is easy and economic to keep, that shows a high degree of similarity in pain perception and response with mammals and is especially able to offer many technical tools for conducting studies.

Zebrafish matches all these characteristics" he said. " Now we are creating transgenic zebrafish that became fluorescent in response to painful stimulations. These transgenic fish can be used for in vivo studies. At first we will use these transgenic fish to characterize better the cellular and molecular mechanisms of pain, but our final goal, if we will find the appropriate funding, is to use them for screening for chemicals with potential analgesic activity."

Other authors of the study include Dr. Valentina Malafoglia and William Raffaeli both at ISAL-Foundation, Institute for Research on Pain, Dr. Marco Colasanti at University of Roma3 and Dr. Darius Balciunas at Temple University.


Story Source:

The above story is based on materials provided by Sbarro Health Research Organization (SHRO). Note: Materials may be edited for content and length.


Journal Reference:

  1. Valentina Malafoglia, Marco Colasanti, William Raffaeli, Darius Balciunas, Antonio Giordano, Gianfranco Bellipanni. Extreme thermal noxious stimuli induce pain responses in zebrafish larvae. Journal of Cellular Physiology, 2013; DOI: 10.1002/jcp.24447

Cite This Page:

Sbarro Health Research Organization (SHRO). "Can the zebrafish help us to search for new pain drugs?." ScienceDaily. ScienceDaily, 3 September 2013. <www.sciencedaily.com/releases/2013/09/130903090908.htm>.
Sbarro Health Research Organization (SHRO). (2013, September 3). Can the zebrafish help us to search for new pain drugs?. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2013/09/130903090908.htm
Sbarro Health Research Organization (SHRO). "Can the zebrafish help us to search for new pain drugs?." ScienceDaily. www.sciencedaily.com/releases/2013/09/130903090908.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins