Featured Research

from universities, journals, and other organizations

New coating may reduce blood clot risk inside stents

Date:
September 5, 2013
Source:
American Heart Association
Summary:
A new stent coating may someday eliminate a common side effect of the treatment.

Coating artery-opening stents with a new compound may someday eliminate a common side effect of the treatment, according to preliminary research in the American Heart Association journal Arteriosclerosis, Thrombosis, and Vascular Biology.

Stents are tiny mesh tubes that prop open clogged arteries so blood will flow freely to heart muscle, relieving chest pain and reducing the risk of heart attack. But implanting a stent damages the inner lining of the artery, triggering overgrowth of smooth muscle in the middle layer of the artery, a process that can re-narrow the passageway as the vessel wall thickens. To prevent this, stents are frequently coated with one of several medications that block smooth muscle growth.

However, the drugs that inhibit re-narrowing don't prevent another possible problem -- blood clots forming inside the vessel with the stent -- and make the side effect more likely. This happens because the medications also interfere with the repair and regrowth of a smooth and healthy layer of blood vessel lining cells (called endothelium) in the area of the stent.

In animal experiments of blood vessel injury, researchers found that a compound called a CTP synthase inhibitor successfully blocked smooth muscle growth and either promoted or didn't interfere with the growth of endothelial cells.

"We hope it may someday provide a long-term fix by supporting repair of the injured endothelium," said Shi-You Chen, Ph.D., senior author of the study and associate professor of physiology in the Department of Physiology and Pharmacology at the University of Georgia College of Veterinary Medicine in Athens. "Most currently available drug-eluting stents also stop the growth of the inner layer of endothelial cells. This delays repair of the stent-injured lining and can trigger inflammation and formation of a blood clot at the injury site, which may severely block coronary blood circulation and damage the heart."

Patients with stents are at the greatest risk for blood clots within the first 30 days after the initial procedure, but the potential for blood clots remains a year or more after stent insertion.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rui Tang, Xiao-Bing Cui, Jia-Ning Wang, Shi-You Chen. CTP Synthase 1, a Smooth Muscle–Sensitive Therapeutic Target for Effective Vascular Repair. Arteriosclerosis, Thrombosis, and Vascular Biology, September 2013

Cite This Page:

American Heart Association. "New coating may reduce blood clot risk inside stents." ScienceDaily. ScienceDaily, 5 September 2013. <www.sciencedaily.com/releases/2013/09/130905203010.htm>.
American Heart Association. (2013, September 5). New coating may reduce blood clot risk inside stents. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2013/09/130905203010.htm
American Heart Association. "New coating may reduce blood clot risk inside stents." ScienceDaily. www.sciencedaily.com/releases/2013/09/130905203010.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins