Featured Research

from universities, journals, and other organizations

New coating may reduce blood clot risk inside stents

Date:
September 5, 2013
Source:
American Heart Association
Summary:
A new stent coating may someday eliminate a common side effect of the treatment.

Coating artery-opening stents with a new compound may someday eliminate a common side effect of the treatment, according to preliminary research in the American Heart Association journal Arteriosclerosis, Thrombosis, and Vascular Biology.

Stents are tiny mesh tubes that prop open clogged arteries so blood will flow freely to heart muscle, relieving chest pain and reducing the risk of heart attack. But implanting a stent damages the inner lining of the artery, triggering overgrowth of smooth muscle in the middle layer of the artery, a process that can re-narrow the passageway as the vessel wall thickens. To prevent this, stents are frequently coated with one of several medications that block smooth muscle growth.

However, the drugs that inhibit re-narrowing don't prevent another possible problem -- blood clots forming inside the vessel with the stent -- and make the side effect more likely. This happens because the medications also interfere with the repair and regrowth of a smooth and healthy layer of blood vessel lining cells (called endothelium) in the area of the stent.

In animal experiments of blood vessel injury, researchers found that a compound called a CTP synthase inhibitor successfully blocked smooth muscle growth and either promoted or didn't interfere with the growth of endothelial cells.

"We hope it may someday provide a long-term fix by supporting repair of the injured endothelium," said Shi-You Chen, Ph.D., senior author of the study and associate professor of physiology in the Department of Physiology and Pharmacology at the University of Georgia College of Veterinary Medicine in Athens. "Most currently available drug-eluting stents also stop the growth of the inner layer of endothelial cells. This delays repair of the stent-injured lining and can trigger inflammation and formation of a blood clot at the injury site, which may severely block coronary blood circulation and damage the heart."

Patients with stents are at the greatest risk for blood clots within the first 30 days after the initial procedure, but the potential for blood clots remains a year or more after stent insertion.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rui Tang, Xiao-Bing Cui, Jia-Ning Wang, Shi-You Chen. CTP Synthase 1, a Smooth Muscle–Sensitive Therapeutic Target for Effective Vascular Repair. Arteriosclerosis, Thrombosis, and Vascular Biology, September 2013

Cite This Page:

American Heart Association. "New coating may reduce blood clot risk inside stents." ScienceDaily. ScienceDaily, 5 September 2013. <www.sciencedaily.com/releases/2013/09/130905203010.htm>.
American Heart Association. (2013, September 5). New coating may reduce blood clot risk inside stents. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2013/09/130905203010.htm
American Heart Association. "New coating may reduce blood clot risk inside stents." ScienceDaily. www.sciencedaily.com/releases/2013/09/130905203010.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins