Featured Research

from universities, journals, and other organizations

Doctors look at treating specific types of pediatric cancer with viral therapy

Date:
September 9, 2013
Source:
Nationwide Children's Hospital
Summary:
Parents do everything they can to protect their children against all of the nasty germs floating around classrooms this time of year. Doctors and researchers, however, are looking into how those same types of common viruses can actually help treat a child who is diagnosed with certain cancers.

Parents do everything they can to protect their children against all of the nasty germs floating around classrooms across the country this time of year. Doctors and researchers at Nationwide Children's Hospital, however, are looking into how those same types of common viruses can actually help treat a child who is diagnosed with certain cancers.

This novel approach is called, viral therapy. It involves slightly altering a virus in the laboratory, injecting it directly into a solid cancer tumor which then causes the tumor to shrink and disappear altogether.

Several years of study into this approach have led scientists to find more and more evidence that oncolytic viruses show promise as anticancer agents with variations of the herpes simplex virus (HSV) among the most commonly used. Viral therapy has been studied in adults, but only a few institutions have studied it in kids.

"Virus therapy is a very promising area of cancer treatment," said Timothy Cripe, MD, PhD, division chief of Hematology/Oncology and Bone Marrow Transplantation at Nationwide Children's. "By injecting the tumor directly with a virus, it will cause the body's immune system to react and attack that tumor while preserving the body's healthy cells."

For the damage that the virus does to the tumor, it does not have any effect on the healthy tissue surrounding the tumor and cells throughout the body. That means there are very few, if any, side effects from the treatment. Further, viral therapy could make a world of difference for pediatric cancer patients that would otherwise be treated with chemotherapy. Those patients would not have to experience the common side effects from chemo including hair loss, fatigue, nausea and weight loss/gain.

Dr. Cripe and his team will soon launch a phase I clinical trial at Nationwide Children's which will study viral therapy for solid cancer tumors in kids. They will be looking at this treatment for cancers such as neuroblastoma and sarcoma.

In March earlier this year, Dr. Cripe, also a faculty member at The Ohio State University College of Medicine, and his team published findings in Molecular Therapy which shed additional light on how viral therapy combined with drugs that attack the tumor blood vessels and simultaneously selectively suppress the immune response within the cancer could be more effective against treating solid tumors.


Story Source:

The above story is based on materials provided by Nationwide Children's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mark A Currier, Francis K Eshun, Allyson Sholl, Artur Chernoguz, Kelly Crawford, Senad Divanovic, Louis Boon, William F Goins, Jason S Frischer, Margaret H Collins, Jennifer L Leddon, William H Baird, Amy Haseley, Keri A Streby, Pin-Yi Wang, Brett W Hendrickson, Rolf A Brekken, Balveen Kaur, David Hildeman, Timothy P Cripe. VEGF Blockade Enables Oncolytic Cancer Virotherapy in Part by Modulating Intratumoral Myeloid Cells. Molecular Therapy, 2013; 21 (5): 1014 DOI: 10.1038/mt.2013.39

Cite This Page:

Nationwide Children's Hospital. "Doctors look at treating specific types of pediatric cancer with viral therapy." ScienceDaily. ScienceDaily, 9 September 2013. <www.sciencedaily.com/releases/2013/09/130909201048.htm>.
Nationwide Children's Hospital. (2013, September 9). Doctors look at treating specific types of pediatric cancer with viral therapy. ScienceDaily. Retrieved August 2, 2014 from www.sciencedaily.com/releases/2013/09/130909201048.htm
Nationwide Children's Hospital. "Doctors look at treating specific types of pediatric cancer with viral therapy." ScienceDaily. www.sciencedaily.com/releases/2013/09/130909201048.htm (accessed August 2, 2014).

Share This




More Health & Medicine News

Saturday, August 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins