Featured Research

from universities, journals, and other organizations

Mosquito bites deliver potential new malaria vaccine

Date:
September 11, 2013
Source:
Elsevier
Summary:
There is hope for new live-attenuated malaria vaccine according to a new study. This work has genetically engineered malaria parasites that are stunted through precise gene deletions, and these could be used as a vaccine that protects against malaria infection.

Can mosquito bites bring a new malaria vaccine?
Credit: ©Elsevier

A study published in Vaccine could provide hope for new live-attenuated malaria vaccine

This study suggests that genetically engineered malaria parasites that are stunted through precise gene deletions (genetically attenuated parasites, or "GAP") could be used as a vaccine that protects against malaria infection. This means that the harmless (attenuated) version of the parasite would interact with the body in the same way as the infective version, but without possibility of causing disease. GAP-vaccination would induce robust immune responses that protect against future infection with malaria.

Related Articles


According to the World Health Organization, there were 219 million documented cases of malaria in 2010, causing the deaths of up to 1.2 million people worldwide. Antimalarial treatments are available to reduce the risk of infection, but as yet there is no effective vaccine against the disease.

Last month, a team of scientists announced the results of a trial with a new kind of malaria vaccine, a whole-parasite preparation weakened by radiation. The trial showed promising results, but the method of vaccination was not optimal, requiring intravenous administration and multiple high doses. This current paper outlines a method of attenuation through genetic engineering rather than radiation, which offers hope for a more consistent vaccine that gives better protection.

"Malaria is one of the world's biggest killers, and threatens 40 percent of the world's population, yet still no effective vaccine exists," said Stefan Kappe, Ph.D., lead author of the paper and professor at Seattle BioMed. "In this paper we show that genetically engineered parasites are a promising, viable option for developing a malaria vaccine, and we are currently engineering the next generation of attenuated parasite strains with the aim to enter clinical studies soon."

For the first time, researchers created a weakened version of the human malaria parasite by altering its DNA. They tested the safety of the new modified parasite by injecting six human volunteers through mosquito bites. Five of the six volunteers showed no infection with the parasite, suggesting that the new genetic technique has potential as the basis for a malaria vaccine.

"Our approach offers a new path to make a protective malaria vaccine that might overcome the limitations of previous development attempts. Genetically engineered parasites potentially provide us with a potent, scalable approach to malaria vaccination," said Kappe. "Our results are very encouraging, providing a strong rationale for the further development of live-attenuated strains using genetic engineering."


Story Source:

The above story is based on materials provided by Elsevier. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michele Spring, Jittawadee Murphy, Robin Nielsen, Megan Dowler, Jason W. Bennett, Stasya Zarling, Jack Williams, Patricia de la Vega, Lisa Ware, Jack Komisar, Mark Polhemus, Thomas L. Richie, Judy Epstein, Cindy Tamminga, Ilin Chuang, Nancy Richie, Michael O’Neil, D. Gray Heppner, Julie Healer, Matthew O’Neill, Hannah Smithers, Olivia C. Finney, Sebastian A. Mikolajczak, Ruobing Wang, Alan Cowman, Christian Ockenhouse, Urszula Krzych, Stefan H.I. Kappe. First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers. Vaccine, 2013; DOI: 10.1016/j.vaccine.2013.08.007

Cite This Page:

Elsevier. "Mosquito bites deliver potential new malaria vaccine." ScienceDaily. ScienceDaily, 11 September 2013. <www.sciencedaily.com/releases/2013/09/130911093049.htm>.
Elsevier. (2013, September 11). Mosquito bites deliver potential new malaria vaccine. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2013/09/130911093049.htm
Elsevier. "Mosquito bites deliver potential new malaria vaccine." ScienceDaily. www.sciencedaily.com/releases/2013/09/130911093049.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins