Featured Research

from universities, journals, and other organizations

Crucial pathway discovered to fight gut infection

Date:
September 11, 2013
Source:
University of Melbourne
Summary:
An international team of researchers has found a crucial pathway for defending the human gut against infection. 

The researchers found virulent E. coli bacteria blocked a pathway that would normally protect the gut from infection. These infections are particularly serious in young children and can result in diarrhoea and other complications such as kidney damage.

The role of this pathway in fighting gut infection was previously unknown but defects in it are associated with inflammatory bowel disease.

The research, published tomorrow in Nature, provides much needed insight into how the gut fights infection.

Lead author Professor Elizabeth Hartland from the University's Department of Microbiology and Immunology said the research improved our understanding of what happens when this pathway doesn't work as well as it should.

"This research provides a model where we can look at how these bacteria switch off a critical pathway in our body that helps fight infection and contributes to normal intestinal function," she said.

"Using this fundamental knowledge, we can conduct further studies and work towards improving therapies and treatments for people with inflammatory bowel disease, which affects around 5 million people worldwide"

The researchers found the diarrhoea-causing bacteria use a needle-like structure to inject a toxin into the gut cell that blocks cell death. This allows the bacteria to survive and spread in the gut, causing a range of diseases.

The injected toxin paralyses the infected cell's ability to send messages to immune cells which would normally sense and eliminate dangerous microbes from the body as well as alert the broader immune system to mount a response to the infection.

"This is a significant contribution to global research in this field as the role of this pathway in intestinal defence and the way bacteria go about blocking this pathway was not known."

Diarrhoeal infections are predominantly a problem in developing countries where sanitation is poor, yet cases of virulent E. coli also occur in developed countries including Australia.

The international study was conducted in collaboration with the Walter and Eliza Hall Institute, Bio21 Institute and international universities.


Story Source:

The above story is based on materials provided by University of Melbourne. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jaclyn S. Pearson, Cristina Giogha, Sze Ying Ong, Catherine L. Kennedy, Michelle Kelly, Keith S. Robinson, Tania Wong Fok Lung, Ashley Mansell, Patrice Riedmaier, Clare V. L. Oates, Ali Zaid, Sabrina Mόhlen, Valerie F. Crepin, Olivier Marches, Ching-Seng Ang, Nicholas A. Williamson, Lorraine A. O’reilly, Aleksandra Bankovacki, Ueli Nachbur, Giuseppe Infusini, Andrew I. Webb, John Silke, Andreas Strasser, Gad Frankel & Elizabeth L. Hartland. A type III effector antagonizes death receptor signalling during bacterial gut infection. Nature, September 2013 DOI: 10.1038/nature12524

Cite This Page:

University of Melbourne. "Crucial pathway discovered to fight gut infection." ScienceDaily. ScienceDaily, 11 September 2013. <www.sciencedaily.com/releases/2013/09/130911132040.htm>.
University of Melbourne. (2013, September 11). Crucial pathway discovered to fight gut infection. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2013/09/130911132040.htm
University of Melbourne. "Crucial pathway discovered to fight gut infection." ScienceDaily. www.sciencedaily.com/releases/2013/09/130911132040.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) — The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) — An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) — Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) — Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins