Featured Research

from universities, journals, and other organizations

Crucial pathway discovered to fight gut infection

Date:
September 11, 2013
Source:
University of Melbourne
Summary:
An international team of researchers has found a crucial pathway for defending the human gut against infection. 

The researchers found virulent E. coli bacteria blocked a pathway that would normally protect the gut from infection. These infections are particularly serious in young children and can result in diarrhoea and other complications such as kidney damage.

The role of this pathway in fighting gut infection was previously unknown but defects in it are associated with inflammatory bowel disease.

The research, published tomorrow in Nature, provides much needed insight into how the gut fights infection.

Lead author Professor Elizabeth Hartland from the University's Department of Microbiology and Immunology said the research improved our understanding of what happens when this pathway doesn't work as well as it should.

"This research provides a model where we can look at how these bacteria switch off a critical pathway in our body that helps fight infection and contributes to normal intestinal function," she said.

"Using this fundamental knowledge, we can conduct further studies and work towards improving therapies and treatments for people with inflammatory bowel disease, which affects around 5 million people worldwide"

The researchers found the diarrhoea-causing bacteria use a needle-like structure to inject a toxin into the gut cell that blocks cell death. This allows the bacteria to survive and spread in the gut, causing a range of diseases.

The injected toxin paralyses the infected cell's ability to send messages to immune cells which would normally sense and eliminate dangerous microbes from the body as well as alert the broader immune system to mount a response to the infection.

"This is a significant contribution to global research in this field as the role of this pathway in intestinal defence and the way bacteria go about blocking this pathway was not known."

Diarrhoeal infections are predominantly a problem in developing countries where sanitation is poor, yet cases of virulent E. coli also occur in developed countries including Australia.

The international study was conducted in collaboration with the Walter and Eliza Hall Institute, Bio21 Institute and international universities.


Story Source:

The above story is based on materials provided by University of Melbourne. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jaclyn S. Pearson, Cristina Giogha, Sze Ying Ong, Catherine L. Kennedy, Michelle Kelly, Keith S. Robinson, Tania Wong Fok Lung, Ashley Mansell, Patrice Riedmaier, Clare V. L. Oates, Ali Zaid, Sabrina Mόhlen, Valerie F. Crepin, Olivier Marches, Ching-Seng Ang, Nicholas A. Williamson, Lorraine A. O’reilly, Aleksandra Bankovacki, Ueli Nachbur, Giuseppe Infusini, Andrew I. Webb, John Silke, Andreas Strasser, Gad Frankel & Elizabeth L. Hartland. A type III effector antagonizes death receptor signalling during bacterial gut infection. Nature, September 2013 DOI: 10.1038/nature12524

Cite This Page:

University of Melbourne. "Crucial pathway discovered to fight gut infection." ScienceDaily. ScienceDaily, 11 September 2013. <www.sciencedaily.com/releases/2013/09/130911132040.htm>.
University of Melbourne. (2013, September 11). Crucial pathway discovered to fight gut infection. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2013/09/130911132040.htm
University of Melbourne. "Crucial pathway discovered to fight gut infection." ScienceDaily. www.sciencedaily.com/releases/2013/09/130911132040.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Costs Keep Mounting

Ebola Costs Keep Mounting

Reuters - Business Video Online (Sep. 23, 2014) — The WHO has warned up to 20,000 people could be infected with Ebola over the next few weeks. As Sonia Legg reports, the implications for the West African countries suffering from the disease are huge. Video provided by Reuters
Powered by NewsLook.com
Ebola Cases Could Reach 1.4 Million Within 4 Months

Ebola Cases Could Reach 1.4 Million Within 4 Months

Newsy (Sep. 23, 2014) — Health officials warn that without further intervention, the number of Ebola cases in Liberia and Sierra Leone could reach 1.4 million by January. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Cases to Triple in Weeks Without Drastic Action

WHO: Ebola Cases to Triple in Weeks Without Drastic Action

AFP (Sep. 23, 2014) — The number of Ebola infections will triple to 20,000 by November, soaring by thousands every week if efforts to stop the outbreak are not stepped up radically, the WHO warned in a study on Tuesday. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
5 Ways Men Can Prevent Most Heart Attacks

5 Ways Men Can Prevent Most Heart Attacks

Newsy (Sep. 23, 2014) — No surprise here: A recent study says men can reduce their risk of heart attack by maintaining a healthy lifestyle, which includes daily exercise. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins