Featured Research

from universities, journals, and other organizations

New HIV-1 replication pathway discovered

Date:
September 18, 2013
Source:
New York University
Summary:
A team of researchers has discovered a new way that HIV-1 reproduces itself, which could advance the search for new ways to combat infection.

Current drug treatments for HIV work well to keep patients from developing AIDS, but no one has found a way to entirely eliminate the virus from the human body, so patients continue to require lifelong treatment to prevent them from developing AIDS.

Now, a team of researchers led by Dr. David N. Levy, Associate Professor of Basic Science and Craniofacial Biology at the New York University College of Dentistry (NYUCD), have discovered a new way that HIV-1 reproduces itself which could advance the search for new ways to combat infection.

For decades, scientists have been confident that HIV-1, the virus that causes AIDS, must insert its genetic material into a cell's DNA in order to reproduce. This process, called "integration," makes the virus a permanent part of the cell. Some of these infected cells can remain as long as the person is alive, and this is one reason why HIV+ individuals must remain on anti-HIV drugs for life.

Dr. Levy's National Institutes of Health (NIH) funded research, "HIV-1 replication without integration," published today on-line in the Journal of Virology, with lead author Dr. Benjamin Trinitι, a post-doctoral fellow in Dr. Levy's laboratory, has shown HIV-1 can sometimes skip this integration step entirely.

"Although this is not the virus' main method for replicating, having this option available can help HIV survive," said Dr. Levy. "These new findings suggest one mechanism by which HIV may be surviving in the face of antiviral drugs, and suggests new avenues for research into eliminating infection."

The integration step is highly inefficient and actually fails up to 99% of the time, leaving most viruses stranded outside of the safe harbor of cell's DNA. It has been assumed that these stranded, or "unintegrated" viruses were unable to reproduce, but Dr. Levy's team has found that if the conditions are right they can generate new viruses that infect new cells.

The team also found that the unintegrated viruses can survive for many weeks in cells, allowing HIV to "hide out" in a dormant state. The ability of HIV-1 to go dormant helps it avoid elimination by antiviral drugs and immune responses.

"There is intense interest by researchers in the idea that new drugs might be developed to help to completely eliminate the virus from infected individuals," said Dr. Levy. "We think that the new replication mechanism we have found could provide a target for drugs designed to eliminate infection."

Dr Levy notes, an interesting phenomenon which other researchers have observed is that some bacteria which live in our mouths can stimulate HIV-1 to emerge from its dormant state.

"NYUCD has some terrific groups of researchers who are expert in oral flora and HIV, so we'll be quite interested in working with them to find out how oral health might influence the new replication pathway my group has discovered," added Dr. Levy.


Story Source:

The above story is based on materials provided by New York University. Note: Materials may be edited for content and length.


Cite This Page:

New York University. "New HIV-1 replication pathway discovered." ScienceDaily. ScienceDaily, 18 September 2013. <www.sciencedaily.com/releases/2013/09/130918111744.htm>.
New York University. (2013, September 18). New HIV-1 replication pathway discovered. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2013/09/130918111744.htm
New York University. "New HIV-1 replication pathway discovered." ScienceDaily. www.sciencedaily.com/releases/2013/09/130918111744.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) — President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) — A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) — A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) — A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins