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Insight into combined radiation injury from nuclear disaster

Date:
October 1, 2013
Source:
Loyola University Health System
Summary:
A nuclear bomb or nuclear reactor accident can produce a deadly combination of radiation exposure and injuries such as burns and trauma. Now the first study of its kind in 50 years is providing new insights into combined radiation injury.

Findings of this study could lead to new treatments for victims, as well as pretreatments for first responders.
Credit: bptu / Fotolia

A nuclear bomb or nuclear reactor accident can produce a deadly combination of radiation exposure and injuries such as burns and trauma.

Now the first study of its kind in 50 years is providing new insights into this phenomenon, called combined radiation injury (CRI).

Researchers at Loyola University Chicago Stritch School of Medicine have shown how CRI causes the intestines to leak bacteria into surrounding tissue. The study also showed that radiation and burns have a synergistic effect that make them far more deadly when they act in combination.

The study is published in the October, 2013 issue of the journal Shock.

Findings could lead to new treatments for victims, as well as pretreatments for first responders, said senior author Elizabeth Kovacs, PhD. First author is Stewart Carter, MD.

“The use of nuclear technology and the potential for its implementation in warfare and terrorism highlight the importance of this study. . . ” researchers concluded. “Insight into the effects of combined radiation injury on the gut will help direct management of survivors of nuclear disaster.”

Normally, cells that line the lumen of the intestine prevent bacteria and bacterial products from leaking out. The cells are held together by “tight junctions.” Radiation can damage and kill these cells, and a burn injury can trigger an inflammatory response that breaks down tight junctions. This effectively opens up the protective lining, allowing bacterial products to leak out of the intestine. Such leaks can cause death by sepsis.

In the study, researchers found that combined radiation and thermal injury triggered 100 times greater leakage of bacteria across the intestinal lining than the leakage seen in control groups exposed to radiation alone, burn alone or no injury at all.

“To our knowledge, we are the first to present gastrointestinal findings of this nature in any CRI model, with the exception of early studies on CRI in the 1960s,” researchers wrote.

Kovacs added: “We hope we never will have to respond to a nuclear disaster. But if such a disaster were to occur, our findings could be part of our preparedness.”

The study is titled “Intestinal Barrier Disruption as a Cause of Mortality in Combined Radiation and Burn Injury.” It is funded by the National Institutes of Health and the Dr. Ralph and Marian C. Falk Medical Research Trust.


Story Source:

The above story is based on materials provided by Loyola University Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. Stewart R. Carter, Anita Zahs, Jessica L. Palmer, Lu Wang, Luis Ramirez, Richard L. Gamelli, Elizabeth J. Kovacs. Intestinal Barrier Disruption as a Cause of Mortality in Combined Radiation and Burn Injury. Shock, 2013; 40 (4): 281 DOI: 10.1097/SHK.0b013e3182a2c5b5

Cite This Page:

Loyola University Health System. "Insight into combined radiation injury from nuclear disaster." ScienceDaily. ScienceDaily, 1 October 2013. <www.sciencedaily.com/releases/2013/10/131001104713.htm>.
Loyola University Health System. (2013, October 1). Insight into combined radiation injury from nuclear disaster. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2013/10/131001104713.htm
Loyola University Health System. "Insight into combined radiation injury from nuclear disaster." ScienceDaily. www.sciencedaily.com/releases/2013/10/131001104713.htm (accessed October 21, 2014).

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