Featured Research

from universities, journals, and other organizations

Nothin' to sneeze at: New treatment for common allergies

Date:
October 3, 2013
Source:
McMaster University
Summary:
Researchers have successfully tested treatments for people with allergies to grasses and to dust mites. The treatments are from a new class of therapy, known as ‘synthetic peptide immuno-regulatory epitopes’, or SPIREs. Positive results, first with a cat allergy therapy and now with house dust mite and grass allergy treatments, suggest that this approach may be used for many common allergies.

Researchers have successfully tested treatments for people with allergies to grasses and to dust mites.
Credit: © luna / Fotolia

Researchers have successfully tested treatments for people with allergies to grasses and to dust mites.

Related Articles


There are two treatments, one for grass allergy, which is commonly known as hay fever, and the other for dust mite allergy. They are expected to be helpful for the millions of people who, as a reaction to grass pollen or the tiny bugs that live in house dust, have sneezing, itching eyes and a running nose that often significantly impacts their productivity at school or work.

The two studies were conducted by Adiga Life Sciences, a joint venture between McMaster University and Circassia, a U.K. based biotechnology company, and was supported by St. Joseph's Healthcare Hamilton.

It is estimated that together, these allergens are responsible for more than 50% of allergic respiratory disease. Between 15 and 25 per cent of the population in North America and Europe is sensitive to pollen from different grass species. One in four people is sensitized to house dust mites, more than any other common allergen, which includes millions of people in these regions.

The treatments are from a new class of therapy, known as 'synthetic peptide immuno-regulatory epitopes', or SPIREs.

The 280 patients in the phase two clinical trial for the grass allergy treatment recorded their allergy symptoms while exposed to grass pollen in a controlled environment, both before treatment and at the end of the hay fever season. Study participants received one of three treatment regimens over three months, completed prior to the beginning of the pollen season. Those who had the optimal short course of therapy had significantly improved symptoms at the end of the season, compared to those who had a placebo. This treatment, called Grass-SPIRE, was well tolerated.

During the clinical trial for the dust mite treatment, 172 patients who received four doses of the treatment over 12 weeks had significantly improved allergy symptoms a year after the start of treatment, compared to patients who received a placebo. The treatment, called HDM-SPIRE, was well tolerated.

"This result is an important validation of the approach we are taking to treat allergic diseases," said Mark Larchι, who led the design of the treatments. "Positive results, first with a cat allergy therapy and now with house dust mite and grass allergy treatments, suggest that this approach may be used for many common allergies."

Larchι is a professor of medicine of the Michael G. DeGroote School of Medicine at McMaster and member of the Firestone Institute for Respiratory Health at St. Joseph's Healthcare Hamilton.

Hay fever is a seasonal response to many different grass pollens which are heaviest in the spring and fall.

Dust mites are close relatives of spiders and ticks and are too small to see without a microscope. They eat skin cells shed by people, and they thrive in warm, humid environments. Upholstered furniture, bedding and carpeting provide an ideal environment for dust mites.


Story Source:

The above story is based on materials provided by McMaster University. Note: Materials may be edited for content and length.


Cite This Page:

McMaster University. "Nothin' to sneeze at: New treatment for common allergies." ScienceDaily. ScienceDaily, 3 October 2013. <www.sciencedaily.com/releases/2013/10/131003111117.htm>.
McMaster University. (2013, October 3). Nothin' to sneeze at: New treatment for common allergies. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2013/10/131003111117.htm
McMaster University. "Nothin' to sneeze at: New treatment for common allergies." ScienceDaily. www.sciencedaily.com/releases/2013/10/131003111117.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) — A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) — Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) — Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) — Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins