Featured Research

from universities, journals, and other organizations

New role for the benefits of oxygen

Date:
October 4, 2013
Source:
The Geisel School of Medicine at Dartmouth
Summary:
During a heart attack when the flow of oxygen-rich blood to a section of the heart is interrupted, and not quickly restored, heart muscle begins dying. Deprived of oxygen and other essential nutrients, cell death continues possibly leading to progressive loss of heart function and congestive heart failure. Rsearchers found that dying heart cells still contain enough oxygen for metabolism, and additional short-term spikes of oxygen keep the cells alive and active.

In a study published in published in EMBO Molecular Medicine, a Dartmouth researcher found that dying heart cells are kept alive with spikes of oxygen.

Related Articles


During a heart attack when the flow of oxygen-rich blood to a section of the heart is interrupted, and not quickly restored, heart muscle begins dying. Deprived of oxygen and other essential nutrients, cell death continues occurring over a period of time leading to progressive loss of heart function and congestive heart failure.

Current therapies are not effective at limiting cell loss -- they only slow down the progression of congestive heart failure.

Periannan Kuppusamy, PhD, professor of radiology at Geisel School of Medicine at Dartmouth, found that dying heart cells still contain enough oxygen for metabolism, and additional short-term spikes of oxygen keep the cells alive and active.

His research team used an animal model of acute myocardial infarction and discovered that daily administration of a higher concentration of oxygen for a short period of time each day induced spikes in myocardial oxygenation, which prevented myocardial injury.

"We all know that oxygen is crucial for survival, but it is intriguing to know that the same oxygen can be used like a drug to treat disease," Kuppusamy says.

Curious about the molecular mechanism of oxygen in treating myocardial injury, he began examining the effect of oxygen on p53, a transcription factor that regulates cell cycle and triggers programmed cell death. To his surprise he saw the 'oxygen spikes' altering the function of p53 from a death-inducing protein, to promoting transcription of genes that help dying cardiac cells survive.

Kuppusamy sees a link between the results of the present study to the age-old practice of breathing exercises for human well-being. He says, "Controlled breathing can increase tissue oxygenation, and if practiced on a daily basis, can lead to suppression of disease progression."

His research at Dartmouth also focusses on the effect of oxygen in cancer therapy.


Story Source:

The above story is based on materials provided by The Geisel School of Medicine at Dartmouth. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rajan Gogna, Esha Madan, Mahmood Khan, Uttam Pati, Periannan Kuppusamy. p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys118acetylation. EMBO Molecular Medicine, 2013; DOI: 10.1002/emmm.201202055

Cite This Page:

The Geisel School of Medicine at Dartmouth. "New role for the benefits of oxygen." ScienceDaily. ScienceDaily, 4 October 2013. <www.sciencedaily.com/releases/2013/10/131004105238.htm>.
The Geisel School of Medicine at Dartmouth. (2013, October 4). New role for the benefits of oxygen. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2013/10/131004105238.htm
The Geisel School of Medicine at Dartmouth. "New role for the benefits of oxygen." ScienceDaily. www.sciencedaily.com/releases/2013/10/131004105238.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins