Featured Research

from universities, journals, and other organizations

Study identifies which bipolar patients will respond to ketamine therapy for depression, pain

Date:
October 13, 2013
Source:
American Society of Anesthesiologists (ASA)
Summary:
Researchers have discovered how to determine which bipolar patients will benefit from Ketamine, a treatment commonly used for depression and pain relief.

Researchers have discovered how to determine which bipolar patients will benefit from Ketamine, a treatment commonly used for depression and pain relief, according to a study presented at the ANESTHESIOLOGY™ 2013 annual meeting.

Two-thirds of patients benefit from Ketamine and using a blood test, researchers can predict which patients will respond favorably.

"Doctors know that very small doses of Ketamine help relieve depression and pain," said Michael Goldberg, M.D., professor and chairman of anesthesiology, and associate dean for education at Cooper Medical School of Rowan University and chief of the Department of Anesthesiology for Cooper University Health Care, Camden, N.J. "But one in three patients do not respond to this treatment. This research will help as we seek ways to provide these patients relief."

Researchers identified the compound that Ketamine breaks down into, which they named HNK (2S, 6S hydroxynorketamine). Additionally, researchers discovered the pattern or 'fingerprint' in the fatty acids of the blood that indicates which patients will respond to HNK.

In the study, 22 patients with bipolar disorder were given intravenous doses of Ketamine. Blood was collected from each patient. Responders and non-responders were identified using a standardized depression rating scale. A positive response was defined as a 50 percent or greater improvement. Additionally, researchers examined metabolic patterns in blood samples.

Researchers discovered there was a difference in how responders and nonresponders metabolized fatty acids, based on the variability in levels of 18 different metabolites.

"These are significant discoveries which should eventually help in the treatment of patients suffering from depression and chronic pain," said Irving Wainer, Ph.D., senior investigator with the Intramural Research Program at the National Institute on Aging, Baltimore. "The next step is to look for the genetic or environmental factors that determine whether a person develops the metabolic pattern that responds to the treatment. We hope this leads to the development of customized or individualized treatment for each patient."


Story Source:

The above story is based on materials provided by American Society of Anesthesiologists (ASA). Note: Materials may be edited for content and length.


Cite This Page:

American Society of Anesthesiologists (ASA). "Study identifies which bipolar patients will respond to ketamine therapy for depression, pain." ScienceDaily. ScienceDaily, 13 October 2013. <www.sciencedaily.com/releases/2013/10/131013163316.htm>.
American Society of Anesthesiologists (ASA). (2013, October 13). Study identifies which bipolar patients will respond to ketamine therapy for depression, pain. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2013/10/131013163316.htm
American Society of Anesthesiologists (ASA). "Study identifies which bipolar patients will respond to ketamine therapy for depression, pain." ScienceDaily. www.sciencedaily.com/releases/2013/10/131013163316.htm (accessed April 19, 2014).

Share This



More Mind & Brain News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Study On Artists' Brain Shows They're 'Structurally Unique'

Study On Artists' Brain Shows They're 'Structurally Unique'

Newsy (Apr. 17, 2014) The brains of artists aren't really left-brain or right-brain, but rather have extra neural matter in visual and motor control areas. Video provided by Newsy
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Are School Dress Codes Too Strict?

Are School Dress Codes Too Strict?

AP (Apr. 16, 2014) Pushing the limits on style and self-expression is a rite of passage for teens and even younger kids. How far should schools go with their dress codes? The courts have sided with schools in an era when school safety is paramount. (April 16) Video provided by AP
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins