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Non-hallucinogenic cannabinoids are effective anti-cancer drugs

Date:
October 14, 2013
Source:
University of St George's London
Summary:
New research has shown that the non-hallucinogenic components of cannabis could act as effective anti-cancer agents.

The anti-cancer properties of tetrahydrocannabinol (THC), the primary hallucinogenic component of cannabis, has been recognised for many years, but research into similar cannabis-derived compounds, known as cannabinoids, has been limited.
Credit: © Stιphane Bidouze / Fotolia

New research has shown that the non-hallucinogenic components of cannabis could act as effective anti-cancer agents.

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The anti-cancer properties of tetrahydrocannabinol (THC), the primary hallucinogenic component of cannabis, has been recognised for many years, but research into similar cannabis-derived compounds, known as cannabinoids, has been limited.

The study was carried out by a team at St George's, University of London. It has been published in the journal Anticancer Research.

The team, led by Dr Wai Liu and colleagues carried out laboratory investigations using a number of cannabinoids, either alone or in combination with each other, to measure their anti-cancer actions in relation to leukemia.

Of six cannabinoids studied, each demonstrated anti-cancer properties as effective as those seen in THC. Importantly, they had an increased effect on cancer cells when combined with each other.

Dr Liu said: "This study is a critical step in unpicking the mysteries of cannabis as a source of medicine. The cannabinoids examined have minimal, if any, hallucinogenic side effects, and their properties as anti-cancer agents are promising.

"These agents are able to interfere with the development of cancerous cells, stopping them in their tracks and preventing them from growing. In some cases, by using specific dosage patterns, they can destroy cancer cells on their own.

"Used in combination with existing treatment, we could discover some highly effective strategies for tackling cancer. Significantly, these compounds are inexpensive to produce and making better use of their unique properties could result in much more cost effective anti-cancer drugs in future."

This latest research is part of a growing portfolio of studies into the medicinal properties of cannabis by the research team at St George's. The next step will be to examine in the laboratory these compounds in combination with existing anti-cancer treatments and study treatment schedules to identify strategies that will maximise their efficacy.

The study examined two forms of cannabidiol (CBD), two forms of cannabigerol (CBG) and two forms of cannabigevarin (CBGV). These represent the most common cannabinoids found in the cannabis plant apart from THC.


Story Source:

The above story is based on materials provided by University of St George's London. Note: Materials may be edited for content and length.


Journal Reference:

  1. Katherine Ann Scott, Sini Shah, Angus George Dalgleish And Wai Man Liu. Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules. Anticancer Research, October 2013

Cite This Page:

University of St George's London. "Non-hallucinogenic cannabinoids are effective anti-cancer drugs." ScienceDaily. ScienceDaily, 14 October 2013. <www.sciencedaily.com/releases/2013/10/131014094105.htm>.
University of St George's London. (2013, October 14). Non-hallucinogenic cannabinoids are effective anti-cancer drugs. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2013/10/131014094105.htm
University of St George's London. "Non-hallucinogenic cannabinoids are effective anti-cancer drugs." ScienceDaily. www.sciencedaily.com/releases/2013/10/131014094105.htm (accessed January 26, 2015).

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