Featured Research

from universities, journals, and other organizations

Researchers discover new approach to improve personalized cancer treatments

Date:
October 15, 2013
Source:
University of Minnesota
Summary:
Researchers have successfully shown that a new method for targeting mutated cells could create a major breakthrough in a personalized medicine approach to treat cancer.

Computer scientists worked with doctors to develop new treatment that would kill cancer cells but spare healthy cells
Credit: University of Minnesota

Researchers from the University of Minnesota, Mayo Clinic, and University of Toronto have successfully shown that a new method for targeting mutated cells could create a major breakthrough in a personalized medicine approach to treat cancer.

The team's findings are published in the Oct. 15 issue of Cancer Research, a journal of the American Association of Cancer Research.

The new research discovers susceptible genes in the cancer cells using synthetic lethal interactions -- pairs of genes in which mutation in either gene alone causes no damage to the cell, but where mutations in both cause the death of the cell.

"When we discover these interactions in human cells, it can hold the key to effective, targeted cancer treatments," said Professor Chad Myers, the lead researcher and computer science and engineering associate professor in the University of Minnesota's College of Science and Engineering. "Specifically, drugs could be used to target the synthetic lethal interaction partners of cancer-associated genetic mutations. These drugs would then effectively kill cancer cells but spare otherwise identical cells lacking the cancer-related genetic alteration."

Myers and his collaborators used research on yeast genes to find synthetic lethality, and then found genes in humans that were similar in structure and evolutionary origin to the yeast cells. Myers worked with Dr. Dennis Wigle, a practicing thoracic surgical oncologist at Mayo Clinic to test those interactions in human cells.

They found two striking cases where synthetic lethal interactions were similar between yeast and human cells. These interactions involve genes that are frequently mutated in specific types of cancer and provide potential new drug targets for these tumors.

"About 40 percent of yeast genes have homologs in humans, we thought that inferring interactions across species may provide a quick way of getting at these interactions," Myers said. "Given our expertise with the yeast interactions, we developed a strategy for narrowing down the large list of interactions to test, based on sequence similarity between the genes and public databases of genes commonly mutated in cancer as well as other features."

Decades of drug discovery research have produced a limited number of targeted therapies for treating cancer. The most commonly used therapies involve delivering high doses of radiation or toxic chemicals to the patient, which can help to suppress tumor growth but also cause substantial damage to normal tissue.

"The strategy of using synthetic lethal interactions to identify drug targets, particularly for 'undruggable' cancer genes is an attractive alternative method for drug target discovery," said Wigle. "This technology is an important means to fully leverage information from sequencing projects for clinical application."


Story Source:

The above story is based on materials provided by University of Minnesota. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. Deshpande, M. K. Asiedu, M. Klebig, S. Sutor, E. Kuzmin, J. Nelson, J. Piotrowski, S. Ho Shin, M. Yoshida, M. Costanzo, C. Boone, D. A. Wigle, C. L. Myers. A Comparative Genomic Approach for Identifying Synthetic Lethal Interactions in Human Cancer. Cancer Research, 2013; 73 (20): 6128 DOI: 10.1158/0008-5472.CAN-12-3956

Cite This Page:

University of Minnesota. "Researchers discover new approach to improve personalized cancer treatments." ScienceDaily. ScienceDaily, 15 October 2013. <www.sciencedaily.com/releases/2013/10/131015113913.htm>.
University of Minnesota. (2013, October 15). Researchers discover new approach to improve personalized cancer treatments. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2013/10/131015113913.htm
University of Minnesota. "Researchers discover new approach to improve personalized cancer treatments." ScienceDaily. www.sciencedaily.com/releases/2013/10/131015113913.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins