Featured Research

from universities, journals, and other organizations

New way to treat chronic kidney disease and heart failure

Date:
October 16, 2013
Source:
St. Michael's Hospital
Summary:
Researchers are using adult bone marrow stem cells as they investigate a completely new way of treating chronic kidney disease and heart failure in rats.

Researchers at St. Michael's Hospital are using adult bone marrow stem cells as they investigate a completely new way of treating chronic kidney disease and heart failure in rats.

Related Articles


Dr. Darren Yuen and Dr. Richard Gilbert were the first to show, in 2010, that enriched stem cells improved heart and kidney function in rats with both diseases.

But they and other scientists wondered about the potential side effects of returning those cells to the body, such as forming tumours.

In a paper published online today in the journal Stem Cells, Drs. Yuen and Gilbert said they have since found that enriched bone marrow stem cells secrete hormones in the petri dish that, if injected into rats, has the same positive impact as the stem cells.

"We've shown that we can use these hormones, collected in the dish, to replicate the beneficial effects of the stem cells in treating animals with chronic kidney disease and heart failure," said Dr. Yuen, a nephrologist. "In our view, this is a significant advance for stem cell therapies because it gets around having to inject stem cells."

Dr. Yuen said they do not yet know what kind of hormone the cells are secreting. Identifying the hormone would be the first step toward the goal of developing a synthetic drug.

Chronic kidney disease is much more prevalent than was once believed, with recent estimates suggesting that up to 5 per cent of the Canadian population may be affected. The number of people with CKD and end-stage renal failure is expected to rise as the population ages and more people develop Type 2 diabetes. People with kidney disease often develop heart disease, and many of them die from heart failure rather than kidney failure.


Story Source:

The above story is based on materials provided by St. Michael's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kim Alexander Connelly, Yanling Zhang, Andrew Advani, Suzanne L. Advani, Kerri Thai, Darren A. Yuen, Richard E. Gilbert. DPP-4 Inhibition Attenuates Cardiac Dysfunction and Adverse Remodeling Following Myocardial Infarction in Rats with Experimental Diabetes. Cardiovascular Therapeutics, 2013; 31 (5): 259 DOI: 10.1111/1755-5922.12005

Cite This Page:

St. Michael's Hospital. "New way to treat chronic kidney disease and heart failure." ScienceDaily. ScienceDaily, 16 October 2013. <www.sciencedaily.com/releases/2013/10/131016213211.htm>.
St. Michael's Hospital. (2013, October 16). New way to treat chronic kidney disease and heart failure. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2013/10/131016213211.htm
St. Michael's Hospital. "New way to treat chronic kidney disease and heart failure." ScienceDaily. www.sciencedaily.com/releases/2013/10/131016213211.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Reuters - Innovations Video Online (Apr. 1, 2015) Israeli scientists says laser bonding of tissue allows much faster healing and less scarring. Amy Pollock has more. Video provided by Reuters
Powered by NewsLook.com
Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins