Featured Research

from universities, journals, and other organizations

New way to treat chronic kidney disease and heart failure

Date:
October 16, 2013
Source:
St. Michael's Hospital
Summary:
Researchers are using adult bone marrow stem cells as they investigate a completely new way of treating chronic kidney disease and heart failure in rats.

Researchers at St. Michael's Hospital are using adult bone marrow stem cells as they investigate a completely new way of treating chronic kidney disease and heart failure in rats.

Dr. Darren Yuen and Dr. Richard Gilbert were the first to show, in 2010, that enriched stem cells improved heart and kidney function in rats with both diseases.

But they and other scientists wondered about the potential side effects of returning those cells to the body, such as forming tumours.

In a paper published online today in the journal Stem Cells, Drs. Yuen and Gilbert said they have since found that enriched bone marrow stem cells secrete hormones in the petri dish that, if injected into rats, has the same positive impact as the stem cells.

"We've shown that we can use these hormones, collected in the dish, to replicate the beneficial effects of the stem cells in treating animals with chronic kidney disease and heart failure," said Dr. Yuen, a nephrologist. "In our view, this is a significant advance for stem cell therapies because it gets around having to inject stem cells."

Dr. Yuen said they do not yet know what kind of hormone the cells are secreting. Identifying the hormone would be the first step toward the goal of developing a synthetic drug.

Chronic kidney disease is much more prevalent than was once believed, with recent estimates suggesting that up to 5 per cent of the Canadian population may be affected. The number of people with CKD and end-stage renal failure is expected to rise as the population ages and more people develop Type 2 diabetes. People with kidney disease often develop heart disease, and many of them die from heart failure rather than kidney failure.


Story Source:

The above story is based on materials provided by St. Michael's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kim Alexander Connelly, Yanling Zhang, Andrew Advani, Suzanne L. Advani, Kerri Thai, Darren A. Yuen, Richard E. Gilbert. DPP-4 Inhibition Attenuates Cardiac Dysfunction and Adverse Remodeling Following Myocardial Infarction in Rats with Experimental Diabetes. Cardiovascular Therapeutics, 2013; 31 (5): 259 DOI: 10.1111/1755-5922.12005

Cite This Page:

St. Michael's Hospital. "New way to treat chronic kidney disease and heart failure." ScienceDaily. ScienceDaily, 16 October 2013. <www.sciencedaily.com/releases/2013/10/131016213211.htm>.
St. Michael's Hospital. (2013, October 16). New way to treat chronic kidney disease and heart failure. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2013/10/131016213211.htm
St. Michael's Hospital. "New way to treat chronic kidney disease and heart failure." ScienceDaily. www.sciencedaily.com/releases/2013/10/131016213211.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins