Featured Research

from universities, journals, and other organizations

Pioneering use of oral cholera vaccine during outbreak

Date:
October 17, 2013
Source:
Public Library of Science
Summary:
A Medecins Sans Frontieres vaccination campaign of more than 300,000 people in Guinea shows feasibility of oral cholera vaccine for control of future epidemics.

In a report publishing October 17th, 2013 in PLOS Neglected Tropical Diseases, the international medical humanitarian organization Doctors Without Borders/Mιdecins Sans Frontiθres (MSF) and its scientific research arm, Epicentre, present results of one of the first-ever, large-scale use of an oral cholera vaccine during a cholera outbreak -- a major breakthrough in the understanding and future control of deadly cholera epidemics.

Using results from a mass vaccination campaign of more than 300,000 people conducted in Guinea last year, MSF and Epicentre show the feasibility of implementing a mass vaccination campaign with oral cholera at the onset of an outbreak, similar to the way reactive vaccination campaigns are conducted when diseases such as measles or meningitis are reported in an area.

Last year, MSF teams in Guinea noticed cases of cholera months ahead of the rainy season. These early cholera cases and other factors, including the lack of a cholera epidemic in Guinea for several years, and the ongoing cholera epidemic in neighboring Sierra Leone, were strong indications to MSF and the Ministry of Health that a major cholera epidemic was imminent.

Starting in April of last year the Guinean Ministry of Health and MSF administered 316,250 doses of vaccine during two vaccination rounds in the coastal districts of Boffa and Forecariah, Guinea over six weeks. All individuals older than 12 months were eligible for vaccination in both rounds. The vaccination campaign was well accepted by the local community and MSF achieved high coverage rates. The two doses vaccine coverage was 75.8% in Boffa and 75.9% in Forecariah, respectively. Almost all people surveyed after the campaign, 98.9 percent, reported that they would be vaccinated again in a future cholera campaign.

Oral cholera vaccine was added to the WHO recommendation for cholera treatment in 2010, but so far has not been commonly used as a public health tool for control of the disease. Concerns about its feasibility, timeliness and acceptability by population, as well as fear of diverting resources from other medical programs have discouraged the use of an oral cholera vaccine.

"With this study, we show that with proper planning and outreach in the communities, it is indeed possible to vaccinate hundreds of thousands of people in a remote area, with a highly mobile population, in a relatively short period of time, against cholera," said Dr. Francisco Luquero, the paper's principal investigator. "However, more evidence is still needed about the feasibility of reactive campaigns in densely populated urban areas. Oral cholera vaccines should not be viewed as a long-term solution for global cholera control. They should be integrated as an additional tool in the global response to cholera outbreaks."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Francisco J. Luquero, Lise Grout, Iza Ciglenecki, Keita Sakoba, Bala Traore, Melat Heile, Alpha Amadou Dialo, Christian Itama, Micaela Serafini, Dominique Legros, Rebecca F. Grais. First Outbreak Response Using an Oral Cholera Vaccine in Africa: Vaccine Coverage, Acceptability and Surveillance of Adverse Events, Guinea, 2012. PLoS Neglected Tropical Diseases, 2013; 7 (10): e2465 DOI: 10.1371/journal.pntd.0002465

Cite This Page:

Public Library of Science. "Pioneering use of oral cholera vaccine during outbreak." ScienceDaily. ScienceDaily, 17 October 2013. <www.sciencedaily.com/releases/2013/10/131017173640.htm>.
Public Library of Science. (2013, October 17). Pioneering use of oral cholera vaccine during outbreak. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2013/10/131017173640.htm
Public Library of Science. "Pioneering use of oral cholera vaccine during outbreak." ScienceDaily. www.sciencedaily.com/releases/2013/10/131017173640.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) — President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) — A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) — Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) — New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins