Featured Research

from universities, journals, and other organizations

New evidence for role of specific virus causing type 1 diabetes

Date:
October 22, 2013
Source:
Suomen Akatemia (Academy of Finland)
Summary:
Type 1 diabetes is a disease caused by the destruction of the insulin-producing cells in the pancreas. It is often diagnosed in childhood and requires life-long treatment with daily insulin injections. It is associated with an increased risk for long-term complications which decrease the quality of life and average life-expectancy.

Type 1 diabetes is a disease caused by the destruction of the insulin-producing cells in the pancreas. It is often diagnosed in childhood and requires life-long treatment with daily insulin injections. It is associated with an increased risk for long-term complications which decrease the quality of life and average life-expectancy.

Related Articles


Currently around 15 million people in the world are affected by this disease, and the number of new cases is rapidly increasing. This rapid increase over the last decades indicates that environmental factors must play an important role in the disease process. Viral infections have been among one of the suspected factors, since many viruses cause diabetes in animals by damaging the insulin-producing cells in the pancreas. Some of them have also been linked to human type 1 diabetes raising the possibility of developing vaccines against these viruses to prevent some of the new cases of type 1 diabetes.

Recently, considerable progress has been made in studies evaluating the possible role of one virus group, called enteroviruses, which have been connected with human type 1 diabetes in a variety of reports. These viruses are common in children, and more than 100 different enterovirus types have been identified in man. A subset of these enteroviruses can cause serious illnesses such as; myocarditis, meningitis, the hand-food- and -mouth disease as well as paralytic disease such as polio. Although the association between type 1 diabetes and enteroviruses has been observed in various studies, until now it was not known which enterovirus types are most responsible for this effect.

Now, for the first time, a group of collaborating investigators have published results from two studies in the leading scientific diabetes journal Diabetes identifying the enterovirus types which are associated with type 1 diabetes. One study is based on children taking part in the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) study, which is a birth cohort study observing children at genetic risk for type 1 diabetes from birth up to clinical diabetes or 15 years of age.

The other study (VirDiab) included children with newly diagnosed diabetes from five European countries. The results from these studies clearly show that members of the group B coxsackieviruses are associated with the risk of type 1 diabetes while the 35 other enterovirus types tested did not show such a connection. These findings are in line with other recent reports suggesting that group B coxsackieviruses can spread to the pancreas and damage the insulin-producing cells.

This new discovery, funded by multiple groups, opens up novel possibilities for future research aimed at developing vaccines against these viruses to prevent type 1 diabetes. Since the group B coxsackieviruses includes only six enterovirus types it may be possible to include all of them in the same vaccine. Effective vaccines have been available for a long time against another enterovirus group, called polioviruses, which includes three enterovirus types.

There is a clear need for a diabetes vaccine since no preventive treatments are currently available for type 1 diabetes. Based on the recent findings, it is estimated that such a vaccine could have the potential for preventing a significant proportion of new cases with type 1 diabetes. More research is needed however to confirm the causal relationship between group B coxsackieviruses and type 1 diabetes and to find out the underlying mechanisms of how these viruses can initiate the type 1 diabetes disease process.


Story Source:

The above story is based on materials provided by Suomen Akatemia (Academy of Finland). Note: Materials may be edited for content and length.


Journal References:

  1. O. H. Laitinen, H. Honkanen, O. Pakkanen, S. Oikarinen, M. M. Hankaniemi, H. Huhtala, T. Ruokoranta, V. Lecouturier, P. Andre, R. Harju, S. M. Virtanen, J. Lehtonen, J. W. Almond, T. Simell, O. Simell, J. Ilonen, R. Veijola, M. Knip, H. Hyoty. Coxsackievirus B1 Is Associated With Induction of β-Cell Autoimmunity That Portends Type 1 Diabetes. Diabetes, 2013; DOI: 10.2337/db13-0619
  2. S. Oikarinen, S. Tauriainen, D. Hober, B. Lucas, A. Vazeou, A. S. Khojine, E. Bozas, P. Muir, H. Honkanen, J. Ilonen, M. Knip, P. Keskinen, M.-T. Saha, H. Huhtala, G. Stanway, C. S. Bartsocas, J. Ludvigsson, K. Taylor, H. Hyoty. Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes. Diabetes, 2013; DOI: 10.2337/db13-0620

Cite This Page:

Suomen Akatemia (Academy of Finland). "New evidence for role of specific virus causing type 1 diabetes." ScienceDaily. ScienceDaily, 22 October 2013. <www.sciencedaily.com/releases/2013/10/131022091721.htm>.
Suomen Akatemia (Academy of Finland). (2013, October 22). New evidence for role of specific virus causing type 1 diabetes. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2013/10/131022091721.htm
Suomen Akatemia (Academy of Finland). "New evidence for role of specific virus causing type 1 diabetes." ScienceDaily. www.sciencedaily.com/releases/2013/10/131022091721.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins