Featured Research

from universities, journals, and other organizations

Sleep apnea associated with subclinical myocardial injury

Date:
October 25, 2013
Source:
American Thoracic Society (ATS)
Summary:
Obstructive sleep apnea (OSA) is known to be associated with an increased incidence of cardiovascular disease. Now a new study indicates that OSA is associated with subclinical myocardial injury, as indicated by increased high sensitivity troponin T (hs-TnT) levels. Elevated hs-TnT levels are predictive of both coronary heart disease (CHD) and heart failure (HF) in the general population.

Obstructive sleep apnea is known to be associated with an increased incidence of cardiovascular disease. Now a new study indicates that OSA is associated with subclinical myocardial injury, as indicated by increased high sensitivity troponin T (hs-TnT) levels. Elevated hs-TnT levels are predictive of both coronary heart disease (CHD) and heart failure (HF) in the general population. This is the first study to demonstrate an independent association between sleep apnea severity and this marker of early myocardial injury.

"Although OSA is associated with increased cardiovascular risk, a causal association has been hard to establish because of the association of OSA with other risk factors," said researcher Amil M. Shah, MD, MPH, of the Brigham and Women's Hospital in Boston. "In our study, we were able to demonstrate that greater OSA severity is independently associated with higher hs-TnT levels, suggesting a role for subclinical myocardial injury in the relationship between OSA and heart failure."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

The study included 1,645 middle-aged and older participants in both the Atherosclerosis Risk in Communities and the Sleep Health Study who were free of CHD and HF at baseline. All subjects underwent overnight home polysomnography. Median follow-up was 12.4 years. OSA severity was categorized as none, mild, moderate, or severe using the respiratory disturbance index.

Hs-TnT levels, but not N terminal pro B-type natriuretic peptide levels (a marker for increased ventricular wall stress), were significantly associated with OSA after adjustment for 17 potential confounders (p=0.02), including age, gender, body mass index, smoking status, hypertension, diabetes, alcohol intake, pulmonary function variables (FEV1 and FVC), COPD status, systolic blood pressure, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, insulin level and estimated glomerular filtration rate (eGFR). In all OSA severity categories, hs-TnT was significantly related to the risk of death or incident heart failure, and this relationship was strongest in the severe OSA group.

Limitations of the study include its cross-sectional design, which precludes conclusions on causality, and a limited number of participants with severe OSA.

"Our results suggest a relationship between subclinical myocardial injury and the increased cardiovascular risk seen in patients with OSA," said Dr. Shah. "Monitoring of hs-TnT levels in these patients may have prognostic value, particularly in patients with severe OSA."


Story Source:

The above story is based on materials provided by American Thoracic Society (ATS). Note: Materials may be edited for content and length.


Journal Reference:

  1. Shah, Ami et al. Sleep Apnea is Associa ted with Subclinical Myocardial Injury in the Community: The ARIC-SHHS Study. American Journal of Respiratory And Critical Care M edicine, October 2013

Cite This Page:

American Thoracic Society (ATS). "Sleep apnea associated with subclinical myocardial injury." ScienceDaily. ScienceDaily, 25 October 2013. <www.sciencedaily.com/releases/2013/10/131025091445.htm>.
American Thoracic Society (ATS). (2013, October 25). Sleep apnea associated with subclinical myocardial injury. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2013/10/131025091445.htm
American Thoracic Society (ATS). "Sleep apnea associated with subclinical myocardial injury." ScienceDaily. www.sciencedaily.com/releases/2013/10/131025091445.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins