Featured Research

from universities, journals, and other organizations

Researchers discover new path to address genetic muscular diseases

Date:
November 4, 2013
Source:
Arizona State University
Summary:
For decades, scientists have searched for treatments for myopathies -- genetic muscular diseases such as muscular dystrophy and ALS, also called Lou Gehrig's disease. Now, an interdisciplinary team of researchers has discovered a new avenue to search for treatment possibilities.

For decades, scientists have searched for treatments for myopathies -- genetic muscular diseases such as muscular dystrophy and ALS, also called Lou Gehrig's disease. Now, an interdisciplinary team of researchers from ASU, Stanford and University of Arizona has discovered a new avenue to search for treatment possibilities.

The team's research findings are featured in an article of the journal Proceedings of the National Academy of Sciences (PNAS).

Under healthy circumstances, individual muscles grow or atrophy based on the demands placed on them. However, in cases of trauma or myopathies, acute muscle loss requires a rapid increase in muscle growth. Such rapid increases are controlled through the activation of an adult stem cell population known as satellite cells. Researchers believe understanding this process is a necessary step toward developing effective therapies for muscle repair.

Jeanne Wilson-Rawls, associate professor in the School of Life Sciences, and her colleagues have examined what role Numb -- a gene known to regulate the degradation of proteins -- plays in promoting muscle growth.

"Based on the proteins it targets, we believed that Numb sat at the 'decision point' where satellite cells either retained their stemness or became muscle fibers," said Wilson-Rawls. "Now we know that in mice, where the Numb gene was mutated, there was another role for the gene."

The researchers found that Numb suppressed Myostatin, a gene that limits muscle growth and can cause muscle atrophy.

"This makes the gene an ideal target for developing drugs aimed at the therapeutic treatments of muscle loss," added Wilson-Rawls. "Our finding demonstrates the linked nature of the two opposing processes of growth and atrophy and opens new avenues to pursue treatments of muscle diseases," said Wilson-Rawls.

"We also need to consider parallel efforts of suppressing the atrophy signaling pathways, while promoting muscle growth in patients with muscular dystrophy," said Alan Rawls, associate professor with the School of Life Sciences and co-author of the paper.


Story Source:

The above story is based on materials provided by Arizona State University. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. M. George, S. Biressi, B. J. Beres, E. Rogers, A. K. Mulia, R. E. Allen, A. Rawls, T. A. Rando, J. Wilson-Rawls. Numb-deficient satellite cells have regeneration and proliferation defects. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1311628110

Cite This Page:

Arizona State University. "Researchers discover new path to address genetic muscular diseases." ScienceDaily. ScienceDaily, 4 November 2013. <www.sciencedaily.com/releases/2013/11/131104095545.htm>.
Arizona State University. (2013, November 4). Researchers discover new path to address genetic muscular diseases. ScienceDaily. Retrieved July 27, 2014 from www.sciencedaily.com/releases/2013/11/131104095545.htm
Arizona State University. "Researchers discover new path to address genetic muscular diseases." ScienceDaily. www.sciencedaily.com/releases/2013/11/131104095545.htm (accessed July 27, 2014).

Share This




More Health & Medicine News

Sunday, July 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins