Featured Research

from universities, journals, and other organizations

Hitting inflammation in the guts

Date:
November 6, 2013
Source:
UCD Conway Institute of Biomolecular & Biomedical Research
Summary:
Researchers have identified a way that a new class of anti-inflammatory drugs may be used to treat inflammatory bowel disease.

Researchers in UCD Conway Institute and Systems Biology Ireland have identified a way that a new class of anti-inflammatory drugs may be used to treat inflammatory bowel disease (IBD).

IBD describes a group of commonly occurring and severe diseases including Crohn's disease and ulcerative colitis. Treatment options for the hallmark symptom of chronically inflamed intestinal tissues are limited, often ultimately requiring surgical removal of inflamed tissue.

A research team led by Professor Cormac Taylor, UCD Conway Institute, have previously shown that a class of drugs called hydroxylase inhibitors may provide a new approach to the treatment of IBD. This study now outlines how this occurs at the molecular level.

Hypoxia is a key microenvironmental feature of inflamed tissues that strongly impacts on the inflammatory processes. A family of oxygen-sensing enzymes called HIF-hydroxylases are responsible for controlling the cellular adaptive response to hypoxia.

This new study, led by Prof Cormac Taylor, Dr Eoin Cummins and Dr Carsten Scholz and published in the Proceedings of the National Academy of Sciences, show that hydroxylase inhibitors work by blocking a pro-inflammatory pathway termed the IL-1 pathway; a key driver of inflammation.

These results give significant new information as to a new level of crosstalk between hypoxia and inflammation and provide a mechanism to explain how this new approach to the control of inflammation may work.

Outlining the results, Dr Eoin Cummins said, "We demonstrate that pharmacologic hydroxylase inhibition down-regulates IL-1b-induced pro-inflammatory NF-kB activity both in vitro and in vivo. Two distinct hydroxylase isoforms, PHD1 and FIH, are acting together to achieve this inhibitory effect, which occurs downstream of TRAF6 activation.

A number of key proteins in the proximal IL-1b signalling pathway were found to interact with PHD1 and FIH and/or be subject to hydroxylation. Based on this data, we hypothesise a key role for hydroxylation as a new post-transcriptional modification in the IL-1b pathway."

"This research stems from studies in our laboratory over the last decade into how cells respond to decreased oxygen levels. We found that cells can adapt to low oxygen levels much like mountain climbers adapt to low oxygen levels at altitude. If we use drugs to mimic this adaptive response in inflammation, it suppresses the inflammatory response" says Professor Taylor.


Story Source:

The above story is based on materials provided by UCD Conway Institute of Biomolecular & Biomedical Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. C. C. Scholz, M. A. S. Cavadas, M. M. Tambuwala, E. Hams, J. Rodriguez, A. v. Kriegsheim, P. Cotter, U. Bruning, P. G. Fallon, A. Cheong, E. P. Cummins, C. T. Taylor. Regulation of IL-1-induced NF-B by hydroxylases links key hypoxic and inflammatory signaling pathways. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1309718110

Cite This Page:

UCD Conway Institute of Biomolecular & Biomedical Research. "Hitting inflammation in the guts." ScienceDaily. ScienceDaily, 6 November 2013. <www.sciencedaily.com/releases/2013/11/131106073600.htm>.
UCD Conway Institute of Biomolecular & Biomedical Research. (2013, November 6). Hitting inflammation in the guts. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2013/11/131106073600.htm
UCD Conway Institute of Biomolecular & Biomedical Research. "Hitting inflammation in the guts." ScienceDaily. www.sciencedaily.com/releases/2013/11/131106073600.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins