Featured Research

from universities, journals, and other organizations

Oxygen levels in tumors affect response to treatment

Date:
November 7, 2013
Source:
Manchester University
Summary:
The genetic make-up of a patient’s tumor could be used to personalize their treatment, and help to decide whether they would benefit from receiving additional drugs as part of their radiotherapy program, according to a recent study.

The genetic make-up of a patient's tumor could be used to personalize their treatment, and help to decide whether they would benefit from receiving additional drugs as part of their radiotherapy program, according to a recent study involving scientists from the Manchester Cancer Research Centre.

Related Articles


tumors with lower levels of oxygen -- known as hypoxia -- often respond less well to radiation therapy. There are several agents that can be given to patients before radiotherapy to reduce hypoxia, but these are not given as standard. Being able to measure how well-oxygenated an individual's tumor is would give doctors a valuable way of identifying which patients might benefit from treatment with hypoxia reducing agents before radiotherapy.

Hypoxia has previously been investigated by looking at the expression of certain genes, and Manchester researchers have come up with a genetic profile for tumors that should indicate the overall level of oxygenation.

Researchers at The University of Manchester, part of the Manchester Cancer Research Centre, carried out the study in patients diagnosed with cancer of the bladder and larynx. These patients subsequently underwent either standard radiotherapy or radiotherapy with the addition of two agents which in combination are known to increase oxygenation: nicotinamide and carbogen.

The team tested patients' tumor samples for 26 genes in order to classify them as more or less hypoxic, and then analyzed whether this hypoxia score related to the results of treatment.

"Our goal is to find ways of predicting how patients will respond to different treatments. Future cancer treatments will be personalized so that patients get the best therapy for their tumor." said Professor Catharine West, who led the research. "Personalizing therapy will not only increase the number of people surviving cancer but also decrease side-effects, as patients would be spared from having treatments that are unlikely to work in their tumor."

A paper recently published in Clinical Cancer Research describes how the group found that for laryngeal tumors, those classed as more hypoxic saw a significant benefit from receiving additional agents as well as radiation therapy. However, in bladder cancer, patients with more hypoxic tumors did not benefit from adding extra agents.

Professor West added: "We will now test how the hypoxia score works in the clinic in a trial starting in December in patients with head and neck cancer. I have studied ways of measuring hypoxia in tumors for many years so this is a very exciting finding that could help us optimize how we use radiotherapy to get the best outcome for patients."


Story Source:

The above story is based on materials provided by Manchester University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Catharine West et al. A 26-gene hypoxia signature predicts benefit from hypoxia-modifying therapy in laryngeal cancer but not bladder cancer. Clinical Cancer Research, September 2013

Cite This Page:

Manchester University. "Oxygen levels in tumors affect response to treatment." ScienceDaily. ScienceDaily, 7 November 2013. <www.sciencedaily.com/releases/2013/11/131107094416.htm>.
Manchester University. (2013, November 7). Oxygen levels in tumors affect response to treatment. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2013/11/131107094416.htm
Manchester University. "Oxygen levels in tumors affect response to treatment." ScienceDaily. www.sciencedaily.com/releases/2013/11/131107094416.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) — The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins