Featured Research

from universities, journals, and other organizations

Bisphenol A is affecting us at much lower doses than previously thought

Date:
November 7, 2013
Source:
Landes Bioscience
Summary:
A group of scientists that study endocrine disruption worked together to update and refine a 2007 review of the low dose effects of BPA. The group not only added hundreds of more recent studies, but they also used an integrative biological approach to scrutinize low dose effects of BPA at multiple levels of biological organization: on cells, animals and human populations.

Bisphenol A (BPA) is a known endocrine disruptor that hijacks the normal responses of hormones. Yet, traditional toxicology studies indicate that only very high doses of this chemical affect exposed animals -- doses as high as 50 mg/kg/day. For the past decade, scientists have used modern scientific techniques to probe the effects of BPA on numerous endpoints that are not examined in those traditional toxicology studies. Examining these non-traditional endpoints reveal a very different story. Because of increased understanding of the mechanisms by which hormones and chemicals that mimic hormones work, it has recently become clear that endocrine disruptors need to be studied at much lower doses.

Related Articles


As a consequence of this new understanding, a group of scientists that study endocrine disruption worked together to update and refine a 2007 review of the low dose effects of BPA. The group not only added hundreds of more recent studies, but they also used an integrative biological approach to scrutinize low dose effects of BPA at multiple levels of biological organization: on cells, animals and human populations.

The findings are striking. When looking at the "low dose" literature as a whole, reproducible effects were seen in animals after exposure to incredibly low doses of BPA. In fact, effective doses were ten to forty times lower than the doses identified in traditional toxicology studies. Several dozen "low dose" studies show effects of BPA at doses that humans are thought to encounter in their everyday lives.

These scientists detail in their article the effects of BPA exposure both in vitro and in vivo, and how it contributes to a large range of health problems in humans, such as polycystic ovarian syndrome, immune response to allergens, behavioral problems and decreased fertility. The effects on wildlife are also widespread.

With the knowledge that such tiny amounts of BPA can have such far-reaching implications for humans and wildlife, stricter regulations of this chemical and other endocrine disruptors should be fast on its heels.


Story Source:

The above story is based on materials provided by Landes Bioscience. Note: Materials may be edited for content and length.


Journal Reference:

  1. Laura N Vandenberg, Shelley Ehrlich, Scott M Belcher, Nira Ben-Jonathan, Dana C Dolinoy, Eric R Hugo, Patricia A Hunt, Retha R Newbold, Beverly S Rubin, Katerine S Saili, Ana M Soto, Hong-Sheng Wang, Frederick S vom Saal. Low dose effects of bisphenol A: An integrated review of in vitro, laboratory animal, and epidemiology studies. Endocrine Disruptors, 2013; 1 (1) DOI: 10.4161/endo.26490

Cite This Page:

Landes Bioscience. "Bisphenol A is affecting us at much lower doses than previously thought." ScienceDaily. ScienceDaily, 7 November 2013. <www.sciencedaily.com/releases/2013/11/131107162300.htm>.
Landes Bioscience. (2013, November 7). Bisphenol A is affecting us at much lower doses than previously thought. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2013/11/131107162300.htm
Landes Bioscience. "Bisphenol A is affecting us at much lower doses than previously thought." ScienceDaily. www.sciencedaily.com/releases/2013/11/131107162300.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Anglerfish Rarely Seen In Its Habitat Will Haunt You

Anglerfish Rarely Seen In Its Habitat Will Haunt You

Newsy (Nov. 22, 2014) For the first time Monterey Bay Aquarium recorded a video of the elusive, creepy and rarely seen anglerfish. Video provided by Newsy
Powered by NewsLook.com
Birds Around the World Take Flight

Birds Around the World Take Flight

Reuters - Light News Video Online (Nov. 22, 2014) An imperial eagle equipped with a camera spreads its wings over London. It's just one of the many birds making headlines in this week's "animal roundup". Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Baby Okapi Born at Houston Zoo

Raw: Baby Okapi Born at Houston Zoo

AP (Nov. 20, 2014) The Houston Zoo released video of a male baby okapi. Okapis, also known as the "forest giraffe", are native to the Democratic Republic of the Congo in Central Africa. Video is mute from source. (Nov. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins