Featured Research

from universities, journals, and other organizations

In animal study, 'cold turkey' withdrawal from drugs triggers mental decline

Date:
November 8, 2013
Source:
Georgetown University Medical Center
Summary:
Can quitting drugs without treatment trigger a decline in mental health? That appears to be the case in an animal model of morphine addiction. Researchers say their observations suggest that managing morphine withdrawal could promote a healthier mental state in people.

Can quitting drugs without treatment trigger a decline in mental health? That appears to be the case in an animal model of morphine addiction. Georgetown University Medical Center researchers say their observations suggest that managing morphine withdrawal could promote a healthier mental state in people.

"Over time, drug-abusing individuals often develop mental disorders," says Italo Mocchetti, PhD, a professor of neuroscience. "It's been thought that drug abuse itself contributes to mental decline, but our findings suggest that 'quitting cold turkey' can also lead to damage."

In the study published in the November issue of Brain, Behavior and Immunity and presented at Neuroscience 2013, Mocchetti and his research colleagues treated the animals with morphine, or allowed them to undergo withdrawal by stopping the treatment. Then, they measured pro-inflammatory cytokines, which can promote damage and cell death, and the protein CCL5, which has various protective effects in the brain.

"Interestingly, we found that treating the addicted animals with morphine both increased the protective CCL5 protein while decreasing pro-inflammatory cytokines, suggesting a beneficial effect," Mocchetti explains. The animals that ween't treated during withdrawal had the opposite results -- decreased CCL5 and increased levels of the damaging cytokines.

"From these findings, it appears that morphine withdrawal may be a causative factor that leads to mental decline, presenting an important avenue for research in how we can better help people who are trying to quit using drugs," concludes Mocchetti.


Story Source:

The above story is based on materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lee A. Campbell, Valeriya Avdoshina, Summer Rozzi, Italo Mocchetti. CCL5 and cytokine expression in the rat brain: Differential modulation by chronic morphine and morphine withdrawal. Brain, Behavior, and Immunity, 2013; 34: 130 DOI: 10.1016/j.bbi.2013.08.006

Cite This Page:

Georgetown University Medical Center. "In animal study, 'cold turkey' withdrawal from drugs triggers mental decline." ScienceDaily. ScienceDaily, 8 November 2013. <www.sciencedaily.com/releases/2013/11/131108112244.htm>.
Georgetown University Medical Center. (2013, November 8). In animal study, 'cold turkey' withdrawal from drugs triggers mental decline. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2013/11/131108112244.htm
Georgetown University Medical Center. "In animal study, 'cold turkey' withdrawal from drugs triggers mental decline." ScienceDaily. www.sciencedaily.com/releases/2013/11/131108112244.htm (accessed September 30, 2014).

Share This



More Mind & Brain News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Do Video Games Trump Brain Training For Cognitive Boosts?

Do Video Games Trump Brain Training For Cognitive Boosts?

Newsy (Sep. 29, 2014) More and more studies are showing positive benefits to playing video games, but the jury is still out on brain training programs. Video provided by Newsy
Powered by NewsLook.com
Your Spouse's Personality May Influence Your Earnings

Your Spouse's Personality May Influence Your Earnings

Newsy (Sep. 26, 2014) Research from Washington University suggest people with conscientious spouses have greater career success. Video provided by Newsy
Powered by NewsLook.com
Can A Blood Test Predict Psychosis Risk?

Can A Blood Test Predict Psychosis Risk?

Newsy (Sep. 26, 2014) Researchers say certain markers in the blood can predict risk of psychosis later in the life. The test can aid in early treatment for the condition. Video provided by Newsy
Powered by NewsLook.com
Harpist Soothes Gorillas, Orangutans With Music

Harpist Soothes Gorillas, Orangutans With Music

AP (Sep. 25, 2014) Teri Tacheny, a harpist, has a loyal following of fans who appreciate her soothing music. Every month, gorillas, orangutans and monkeys amble down to hear her play at the Como Park Zoo in Minnesota. (Sept. 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins