Featured Research

from universities, journals, and other organizations

Experimental regimen tested for small cell lung cancer

Date:
November 13, 2013
Source:
Cedars-Sinai Medical Center
Summary:
Small cell lung cancer, which includes oat cell carcinoma, is a more aggressive disease than other types of lung cancer and often is more advanced at the time of diagnosis. Despite the severity of the disease, the standard-of-care treatment remains the same today as it was nearly 30 years ago. A new clinical trial may improve treatment approaches and combat disease recurrence.

Alain C. Mita, MD, is fighting an uphill battle against small cell lung cancer. Despite the severity of the disease, the standard-of-care treatment remains the same today as it was nearly 30 years ago.

Related Articles


Small cell lung cancer, which includes oat cell carcinoma, is a more aggressive disease than other types of lung cancer and often is more advanced at the time of diagnosis. Smoking is the most common cause of the diagnosis and can be diagnosed even decades after an individual has quit. At advanced stages of the disease, it is incurable in the vast majority of patients, with a median survival less than 12 months.

Mita said that following a diagnosis of small cell lung cancer, most patients opt for immediate chemotherapy using the standard-of-care chemotherapy's etoposide and cisplatin -- two drugs developed more than three decades ago. This standard chemotherapy regimen responds well initially, many times putting patients into remission. But, within months, most patients relapse and their disease recurs.

Today, a new Cedars-Sinai Phase I-II clinical trial may improve treatment approaches and combat disease recurrence. But first, Mita needs to find patients to participate in the clinical trial.

"Our team of physician scientists is committed to advancing treatment options for patients diagnosed with small cell lung cancer and other types of lung disease," said Mita, co-director of the Experimental Therapeutics Program at the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute. "The eligibility criteria for this specific clinical trial can be a challenge, as patients must have no treatment history. Our team encourages patients and their treating physician to consider available clinical trials that include the combination of the standard of care and a novel agent."

The approach being tested in the clinical trial works by combining the standard-of-care chemotherapy (etoposide and cisplatin) with a NOTCH inhibitor (OMP-59R5), a targeted therapy aimed to directly attack cancerous stem cells.


Story Source:

The above story is based on materials provided by Cedars-Sinai Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Cedars-Sinai Medical Center. "Experimental regimen tested for small cell lung cancer." ScienceDaily. ScienceDaily, 13 November 2013. <www.sciencedaily.com/releases/2013/11/131113102050.htm>.
Cedars-Sinai Medical Center. (2013, November 13). Experimental regimen tested for small cell lung cancer. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2013/11/131113102050.htm
Cedars-Sinai Medical Center. "Experimental regimen tested for small cell lung cancer." ScienceDaily. www.sciencedaily.com/releases/2013/11/131113102050.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins