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Hybrid heart valve is strong, durable in early tests

Date:
November 18, 2013
Source:
American Heart Association
Summary:
A hybrid heart valve created from thin and highly elastic mesh embedded within layers of human cells was strong and durable in a study.

A hybrid heart valve created from thin and highly elastic mesh embedded within layers of human cells was strong and durable in a study presented at the American Heart Association's Scientific Sessions 2013.

Researchers created a three-dimensional cell culture by coating a scaffold of nickel-titanium alloy (Nitinol), used for devices that require flexibility and motion, with layers of smooth muscle, connective tissue and lining cells. The valves performed well in a heart simulator, opening and closing under various pressures and remaining stable and strong throughout the tests.

A durable, regenerating hybrid heart valve would be an important advance because previous attempts to create tissue-engineered heart valves from patients' cells have been unsatisfactory. All the prior methods entail significant limitations due to structural vulnerability, short-term functionality and mechanical properties of the tissue-engineered valves.


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The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


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American Heart Association. "Hybrid heart valve is strong, durable in early tests." ScienceDaily. ScienceDaily, 18 November 2013. <www.sciencedaily.com/releases/2013/11/131118081257.htm>.
American Heart Association. (2013, November 18). Hybrid heart valve is strong, durable in early tests. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2013/11/131118081257.htm
American Heart Association. "Hybrid heart valve is strong, durable in early tests." ScienceDaily. www.sciencedaily.com/releases/2013/11/131118081257.htm (accessed April 17, 2014).

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