Featured Research

from universities, journals, and other organizations

Novel study charts aggressive prostate cancer

Date:
November 18, 2013
Source:
Cedars-Sinai Medical Center
Summary:
Many patients diagnosed with prostate cancer have indolent, slow-growing forms of the disease that are not life-threatening. However, more than 30,000 American men will die from aggressive prostate cancer this year. This sharp contrast between low-risk and aggressive disease presents a challenge for many researchers and physicians. Investigators have made extensive progress in understanding the molecular mechanisms of disease progression.

Many patients diagnosed with prostate cancer have indolent, slow-growing forms of the disease that are not life-threatening. However, more than 30,000 American men will die from aggressive prostate cancer this year alone. This sharp contrast between low-risk and aggressive disease presents a challenge for many researchers and physicians as they diagnose patients and also determine the prognosis of the men with the most aggressive forms of prostate cancer.

Investigators in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute have made extensive progress in understanding the molecular mechanisms of disease progression. These results may help scientists better understand the prognosis of patients diagnosed with advanced prostate cancer. The study, published in the journal Cell Cycle and led by Dolores Di Vizio, MD, PhD, may ultimately lead to the development of new biomarkers for not only prognosis, but also a patient's potential response to therapy.

"One of the long-standing difficulties in treating men with advanced prostate cancer has been predicting the response to given therapies or treatments," said Di Vizio, associate professor in the Department of Surgery, Department of Pathology and Laboratory Medicine and Department of Biomedical Sciences. "These latest research findings provide tangible insight into the molecular and structural phenomena that result in prostate cancer metastases. They have the potential to create a new source of biomarkers and an innovative standard of care. These findings may also help distinguish individualized treatment plans best suited for each patient."

The new source of biomarkers is large oncosomes, which are vesicles released from aggressive prostate cancer cells with highly migratory features. These large oncosomes carry tumor molecules and have been shown in previous studies to contribute to tumor progression. This study demonstrates, for the first time in human samples, that identification of circulating large oncosomes can be an indicator of patients with more aggressive, treatment-resistant disease. Also notable, researchers found that large oncosomes contain microRNA, a molecule that regulates several biological processes now proven to influence tumor progression.

At the Cedars-Sinai Urologic Oncology Program, researchers and physicians work in close collaboration to discover personalized options for patients with indolent prostate disease to those with aggressive cancer. This latest study will amplify the genetic and molecular understanding of aggressive prostate cancer.

"Many of the latest research developments and treatments for urologic cancers have been initiated from Cedars-Sinai investigators and physicians," said Robert Figlin, MD, FACP, associate director of the Samuel Oschin Comprehensive Cancer Institute, professor of Medicine and Biomedical Sciences and the Steven Spielberg Family Chair in Hematology Oncology. "These latest research observations may identify novel ways to measure a patient's prognosis and are just a stepping stone for the many discoveries moving down the pipeline in our cancer institute."


Story Source:

The above story is based on materials provided by Cedars-Sinai Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Matteo Morello, Valentina R Minciacchi, Paola de Candia, Julie Yang, Edwin Posadas, Hyung Kim, Duncan Griffiths, Neil Bhowmick, Leland WK Chung, Paolo Gandellini, Michael R Freeman, Francesca Demichelis, Dolores Di Vizio. Large oncosomes mediate intercellular transfer of functional microRNA. Cell Cycle, 2013; 12 (22): 59 DOI: 10.4161/cc.26539

Cite This Page:

Cedars-Sinai Medical Center. "Novel study charts aggressive prostate cancer." ScienceDaily. ScienceDaily, 18 November 2013. <www.sciencedaily.com/releases/2013/11/131118091424.htm>.
Cedars-Sinai Medical Center. (2013, November 18). Novel study charts aggressive prostate cancer. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2013/11/131118091424.htm
Cedars-Sinai Medical Center. "Novel study charts aggressive prostate cancer." ScienceDaily. www.sciencedaily.com/releases/2013/11/131118091424.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins