Featured Research

from universities, journals, and other organizations

New technique identifies pathogens in patient samples faster, in great detail

Date:
December 2, 2013
Source:
American Society for Microbiology
Summary:
A team of Danish investigators has shown how to identify pathogens faster, directly from clinical samples.

A team of Danish investigators has shown how to identify pathogens faster, directly from clinical samples. The research, published online ahead of print in the Journal of Clinical Microbiology appears in the journal's January 2014 issue.

Related Articles


The investigators used a technique known as whole genome sequencing to identify and completely characterize bacteria causing urinary tract infections. In just 18 hours, they identified the culprit microorganisms, characterized the pathogens' patterns of antibiotic susceptibility, and identified specific strains.

"Using conventional methodologies this would have taken several days to weeks, and even using whole genome sequencing on cultured bacteria would have taken an extra day," says Frank M. Aarestrup of the Technical University of Denmark, Lyngby, an author on the study.

Their work will help patients heal more quickly and avoid unnecessarily prolonged illness and even death. It will also help prevent outbreaks of hospital-acquired disease, and identify emerging infections.

"Rapid identification of the causative agent, and of any antibiotic resistance is crucial to choosing the correct treatment for individual patients," says Aarestrup. "Choosing the wrong antibiotic will lead to longer infections and in the worst case, deaths."

The investigators also identified bacteria in the patient samples that they did not detect using conventional techniques. "Lactobacillus iners, Gardnerella vaginalis, Prevotella, and A. urinae have all been implicated in [urinary tract infections], even though their precise roles as pathogens and normal colonizers of the genital tract have not been firmly established," write the researchers. They note that by conventional methods A. urinae is rarely identified but frequently misclassified.

The ability to identify strains in patients with repeated infections enables the doctor to know whether the patient's infection is new, or recurrent. And the typing of bacterial strains enables rapid comparison of bacteria from different patients, so that doctors can detect the spread of infections within the hospital, and identify emerging infections.

"Whole genome sequencing may still be too expensive for routine use in most clinical microbial laboratories," the researchers write. But they predict that rapidly falling prices and automation will render it a standard technology for infection detection and control, in and out of the hospital.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. H. Hasman, D. Saputra, T. Sicheritz-Ponten, O. Lund, C. A. Svendsen, N. Frimodt-Moller, F. M. Aarestrup. Rapid whole genome sequencing for the detection and characterization of microorganisms directly from clinical samples. Journal of Clinical Microbiology, 2013; DOI: 10.1128/JCM.02452-13

Cite This Page:

American Society for Microbiology. "New technique identifies pathogens in patient samples faster, in great detail." ScienceDaily. ScienceDaily, 2 December 2013. <www.sciencedaily.com/releases/2013/12/131202172021.htm>.
American Society for Microbiology. (2013, December 2). New technique identifies pathogens in patient samples faster, in great detail. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2013/12/131202172021.htm
American Society for Microbiology. "New technique identifies pathogens in patient samples faster, in great detail." ScienceDaily. www.sciencedaily.com/releases/2013/12/131202172021.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins