Featured Research

from universities, journals, and other organizations

Home testing devices could monitor epilepsy, drug levels, reduce clinical visits

Date:
December 9, 2013
Source:
American Epilepsy Society (AES)
Summary:
Medications remain the mainstay of epilepsy treatment, and to date there are no FDA-approved devices that provide an accurate means of detection for generalized tonic-clonic seizures (GTCS), or convulsions, during activities of daily living. Two new studies provide data that warrants the development of non-invasive devices with the capability to signal the onset of an epileptic seizure and could be crucial to optimal patient dosing.

Medications remain the mainstay of epilepsy treatment, and to date there are no FDA-approved devices that provide an accurate means of detection for generalized tonic-clonic seizures (GTCS), or convulsions, during activities of daily living. Two new studies presented at the American Epilepsy Society's 67th Annual Meeting in Washington D.C. provide data that warrants the development of non-invasive devices with the capability to signal the onset of an epileptic seizure and could be crucial to optimal patient dosing.

Interim analysis that aims to validate a seizure detection software algorithm was presented to support the development of a non-invasive detection device with the ability to measure electromyography (EMG) signals. Patients in this study were asked to wear an arm-device that detected all GTCS within 30 seconds of arm motor action. Twenty-nine patients with a history of seizures were enrolled in the study while in the hospital Epilepsy Monitoring Unit for routine EEG monitoring.

"Our study demonstrates the feasibility to detect generalized tonic-clonic seizures with an arm device analyzing muscle activity during daily living. We were able to capture the GTCS through analysis of EMG signals and confirmed these seizures using video-EEG (VEEG) recordings. The software algorithm was optimized using baseline measurements of maximum voluntary muscle contraction (MVC). In every instance that a GTCS was recorded by vEEG, it was also captured by EMG," said Akos Szabo, MD, the lead researcher of the study.

The results determined that the seizure detection algorithm appeared superior to the other devices currently under investigation or currently commercialized. No false alarms were triggered during activities of normal living.

In a related study conducted by an interdisciplinary team that includes clinician and research experts in epilepsy from the University of Texas Houston, and bioengineers from Rice University, programmable Bio-Nano-Chips (p-BNCs) are presented here in their first application as a non-invasive, repeatable and adaptable alternative to serial serum antiepileptic drug measurements. This study provides a report on progress towards the development of a realistic saliva-based BNC system demonstrating proof of concept of simultaneous detection and quantitation of two commonly used antiepileptic drugs -- phenytoin (PHT) and phenobarbital (PHB). Advantages offered by this technology include the potential for the patients or their caregiver to monitor the levels of antiepileptic drugs in their system, always in a non-invasive, cost effective manner outside the doctor's office.

"These bio-nano-chips, or "labs on a chip" as we like to call them, are a new generation of compact, programmable chemical processors that will satisfy the urgent need for non-invasive, adaptable and cost effective alternatives to blood test," said Giridhar P. Kalamangalam, MD.

The BNC calibration signals are robust and provide ultra-low reliable limits of detection, and compare favorably to the in-lab reference or gold standards. Further work aims to produce a practical point of care diagnostic, eventually a hand-held device hosting a disposable, credit card-sized lab card that will empower patients to monitor drug intake on their own.


Story Source:

The above story is based on materials provided by American Epilepsy Society (AES). Note: Materials may be edited for content and length.


Cite This Page:

American Epilepsy Society (AES). "Home testing devices could monitor epilepsy, drug levels, reduce clinical visits." ScienceDaily. ScienceDaily, 9 December 2013. <www.sciencedaily.com/releases/2013/12/131209143250.htm>.
American Epilepsy Society (AES). (2013, December 9). Home testing devices could monitor epilepsy, drug levels, reduce clinical visits. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2013/12/131209143250.htm
American Epilepsy Society (AES). "Home testing devices could monitor epilepsy, drug levels, reduce clinical visits." ScienceDaily. www.sciencedaily.com/releases/2013/12/131209143250.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins