Featured Research

from universities, journals, and other organizations

Tumor-suppressing genes could play important role in obesity, diabetes, cancer

Date:
December 11, 2013
Source:
Temple University
Summary:
The function of two tumor-suppressing genes could play a vital role in helping to control obesity and other diseases such as diabetes, heart disease and cancer.

The function of two tumor-suppressing genes could play a vital role in helping to control obesity and other diseases such as diabetes, heart disease and cancer, according to researchers in Temple University's Sbarro Institute for Cancer Research and Molecular Medicine.

Related Articles


The researchers published their findings, "Silencing of RB1 and RB2/p130 during adipogenesis of bone marrow stromal cells results in dysregulated differentiation," in the Feb. 1, 2014, issue (online Nov. 25) of the journal Cell Cycle.

"We found that these two genes of the retinoblastoma family, Rb1 and Rb2/p130, are key proteins in regulating the formation and function of fat tissue in the body," said Antonio Giordano, director of the Sbarro Institute and one of the paper's lead authors. "If these proteins are not functioning properly, they are unable to control the formation of fat tissue in the body, so you have a continuous formation of fat tissue."

Giordano said that many people believe that fat tissue is inert, but it is actually a very dynamic tissue and plays a very vital role in producing a number of important proteins in the human genome. "Everyone always thinks of fat tissue in negative terms," he said.

"Fat tissue does play an important function by producing molecules that assist bone marrow to function, grow and produce all three blood cell types: red, white and platelets," said Umberto Galderisi, associate professor of biology at the University of Naples in Italy and a co-author of the study. "But if Rb1 and/or Rb2/p130 are damaged, they can deregulate the fat tissue and cause an overproduction, which can alter the bone marrow's ability to produce those necessary blood cells."

In their paper, the researchers suggest that in addition to altering the bone marrow's ability to assist in the production of blood cells, the overproduction of fat tissue can lead to obesity, which has been linked to several diseases, including diabetes, cardiovascular disease, cancer, and in older people, anemia.

"Fat tissue may also feed and sustain the growth of cancer cells in the body, which helps to explain the link between obesity and cancer," said Giordano, who discovered Rb2/p130 in the early 1990s while a researcher in Temple's Fels Institute for Cancer Research and Molecular Medicine.

Galderisi, also an adjunct professor of biology at Temple, said that understanding this mechanism for regulating the activity and the life of bone-marrow fat cells could pave the way for the development of therapies that might restore the proper function of fat cells, and be useful in the treatment of obesity and its related diseases.


Story Source:

The above story is based on materials provided by Temple University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Antonio Giordano et al. Silencing of RB1 and RB2/p130 during adipogenesis of bone marrow stromal cells results in dysregulated differentiation. Cell Cycle, February 2014

Cite This Page:

Temple University. "Tumor-suppressing genes could play important role in obesity, diabetes, cancer." ScienceDaily. ScienceDaily, 11 December 2013. <www.sciencedaily.com/releases/2013/12/131211131246.htm>.
Temple University. (2013, December 11). Tumor-suppressing genes could play important role in obesity, diabetes, cancer. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2013/12/131211131246.htm
Temple University. "Tumor-suppressing genes could play important role in obesity, diabetes, cancer." ScienceDaily. www.sciencedaily.com/releases/2013/12/131211131246.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins