Featured Research

from universities, journals, and other organizations

Modified T cells effective in treating blood-borne cancers, study shows

Date:
December 11, 2013
Source:
National Cancer Institute (NCI) at NIH
Summary:
Findings from two clinical trials evaluating the use of genetically modified immune system T cells as cancer therapy have been released and results shared.

At the 2013 American Society of Hematology meeting in Dec. 2013, James Kochenderfer, M.D., investigator in the Experimental Transplantation and Immunology Branch, NCI, presented findings from two clinical trials evaluating the use of genetically modified immune system T cells as cancer therapy. These studies were performed in close collaboration with Steven A. Rosenberg, M.D., Ph.D., chief of the Surgery Branch, NCI, who is the principle investigator in the first study noted.

Related Articles


These reports represent important advances in the understanding of gene therapy for treatment of advanced blood-borne cancers. In the first study, 15 adult patients had their T cells removed, were treated with chemotherapy, and then were given an infusion of their own T cells which had been genetically modified in the lab. The first report of the success of this type of therapy in lymphomas came in 2010 by Kochenderfer and Rosenberg in a patient who remains progression-free over 42 months after treatment. This team has now demonstrated that this same approach is effective in patients with diffuse large B-cell lymphoma, the most common type of non-Hodgkin lymphoma. Six patients in the trial achieved complete remission and six achieved partial remission. This approach offers an option for patients with chemotherapy-resistant large B-cell cancer who are not good candidates for other forms of stem cell transplantation.

In the second study, researchers used genetically modified T cells to treat B-cell cancers, such as leukemia and lymphoma, that did not fully respond to transplantation of stem cells from a donor. The study enrolled 10 patients who received no treatment except one infusion of genetically modified T cells that were obtained from related or unrelated stem cell transplant donors. Three of 10 patients experienced significant disease regression, with one patient showing complete remission. Significantly, none of the patients experienced graft-versus-host disease (GVHD). Toxicities were mild, and resolved within two weeks. The results are encouraging because they show that small numbers of modified T cells can cause regression of highly treatment-resistant B-cell cancers without causing GVHD. This finding indicates a possible new treatment approach for patients with aggressive forms of these cancers that have proven resistant to other treatment approaches, including stem cell transplantation from donors.


Story Source:

The above story is based on materials provided by National Cancer Institute (NCI) at NIH. Note: Materials may be edited for content and length.


Cite This Page:

National Cancer Institute (NCI) at NIH. "Modified T cells effective in treating blood-borne cancers, study shows." ScienceDaily. ScienceDaily, 11 December 2013. <www.sciencedaily.com/releases/2013/12/131211185050.htm>.
National Cancer Institute (NCI) at NIH. (2013, December 11). Modified T cells effective in treating blood-borne cancers, study shows. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2013/12/131211185050.htm
National Cancer Institute (NCI) at NIH. "Modified T cells effective in treating blood-borne cancers, study shows." ScienceDaily. www.sciencedaily.com/releases/2013/12/131211185050.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins