Featured Research

from universities, journals, and other organizations

Different parents, different children: bladder cancers arise from different stem cells

Date:
December 17, 2013
Source:
University of Colorado Cancer Center
Summary:
A study published shows that progenitor cells that create dangerous, muscle-invasive bladder cancer are different than the progenitor cells that create non-muscle invasive bladder cancer. Though these two cancers grow at the same site, they are different diseases.

Bladder cancer will kill upward of 170,000 people worldwide this year, but bladder cancer isn't fatal in the bladder. Instead, in order to be fatal the disease must metastasize to faraway sites. The question has been this: does localized, non-muscle invasive (NMI) bladder cancer eventually become the more dangerous, muscle-invasive (MI) form of the disease, or are NMI and MI bladder cancers genetically distinct from the start?

Related Articles


A University of Colorado Cancer Center study published today in the journal Stem Cells shows it's the latter: the progenitor cells that create MI bladder cancer are different than the progenitor cells that create NMI bladder cancer. Though these two cancers grow at the same site, they are different diseases.

"This work provides an important new perspective on how we look at bladder cancer biology," says Dan Theodorescu, MD, PhD, director of the University of Colorado Cancer Center and the study's senior author.

The group including first author Garrett Dancik, PhD, genetically profiled two cell types that could give rise to bladder cancer -- the basal and umbrella layers of the normal bladder lining (urothelium) -- to discover the gene signatures specific to each of these cell populations.

Then the group compared these gene signatures to human bladder cancer samples. The tumor samples were distinct: those with the signature of umbrella cells were likely to be lower stage and patients eventually had favorable outcomes; tumors with the signatures of basal layer cells were likely to be higher stage and patients eventually had worse outcomes.

"We saw a fairly stark difference between these tumor types: those with basal signatures were distinctly more aggressive than those with umbrella signatures," Theodorescu says. In fact, these signatures predicted tumor stage and patient survival better than many existing prognostic markers.

"Our results suggests that NMI cells arise from non-basal cells, whereas MI tumors arise from basal cells," Theodorescu says.

"This may be an important biomarker for prognosis," Theodorescu says. "With additional testing, we could use the signature to predict how aggressive a bladder cancer is likely to be. Knowing the risk can help doctors and patients make informed treatment decisions."


Story Source:

The above story is based on materials provided by University of Colorado Cancer Center. The original article was written by Garth Sundem. Note: Materials may be edited for content and length.


Cite This Page:

University of Colorado Cancer Center. "Different parents, different children: bladder cancers arise from different stem cells." ScienceDaily. ScienceDaily, 17 December 2013. <www.sciencedaily.com/releases/2013/12/131217170856.htm>.
University of Colorado Cancer Center. (2013, December 17). Different parents, different children: bladder cancers arise from different stem cells. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2013/12/131217170856.htm
University of Colorado Cancer Center. "Different parents, different children: bladder cancers arise from different stem cells." ScienceDaily. www.sciencedaily.com/releases/2013/12/131217170856.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins