Featured Research

from universities, journals, and other organizations

Using maths, researchers seek to improve success in transplants

Date:
December 24, 2013
Source:
Investigación y Desarrollo
Summary:
Given that 10.5 % of patients who receive a transplant reject the new organ, researchers are working in the design of a tool capable of preventing this problem. The process consists in knowing the type of proteins in charge of metabolizing the drugs (enzymes) for each patient which would, helped by a mathematical model, allow to establish the exact dose needed of the immunosuppressive drugs required.

Given that 10.5 % of patients who receive a transplant reject the new organ, researchers at the Center of Research and Advanced Studies of the National Polytechnic Institute (Cinvestav) are working in the design of a tool capable of preventing this problem. The process consists in knowing the type of proteins in charge of metabolizing the drugs (enzymes) for each patient which would, helped by a mathematical model, allow to establish the exact dose needed of the immunosuppressive drugs required.

Related Articles


This method will be capable of giving an effective certainty at the moment of establishing the treatment, will also save time and decrease rejection, increasing the quality of life, allowing the survival of more patients and optimizing the health system, informed Gilberto Castañeda Hernández from the department of Pharmacology.

According to the researcher, the enzymes that process the drugs have various grades of activity, so the immunosuppressive can be eliminated slowly or rapidly. Hence, the necessity of knowing, using genetic studies, what kind of proteins each person has to determine the adequate portion of the drug.

Every study is being carried in order to create a mathematical algorithm that will indicate for each person, using their genetics, size, age, current medication and time since the transplant, what should their immunosuppressive drug dosage should be.

Currently, the quantity of drug to be administrated is determined by trial and error; however, this process takes long and gives place to complications that are translated to an acute rejection.

"For example, the dosage that is used in Germany of the drug Nifedipine is not adequate for Mexicans because it gives them headaches, tachycardia and vasodilation, among other problems," says Castañeda Hernández.

The challenge will be to identify the patients that quickly metabolize the immunosuppressive such as Tacrolimus and Ciclosporin. "In Mexico both exist and its dosage is not the same as used in Europe or the United States; we have to find our own genetic variations."

In Mexico, a window of opportunity is to apply this system to kids, making it possible to determine the immunosuppressive treatment correctly. The child population has a special metabolism because of its development; hence, applying the analysis tools would have better results, assured Castañeda Hernández.


Story Source:

The above story is based on materials provided by Investigación y Desarrollo. Note: Materials may be edited for content and length.


Cite This Page:

Investigación y Desarrollo. "Using maths, researchers seek to improve success in transplants." ScienceDaily. ScienceDaily, 24 December 2013. <www.sciencedaily.com/releases/2013/12/131224183545.htm>.
Investigación y Desarrollo. (2013, December 24). Using maths, researchers seek to improve success in transplants. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2013/12/131224183545.htm
Investigación y Desarrollo. "Using maths, researchers seek to improve success in transplants." ScienceDaily. www.sciencedaily.com/releases/2013/12/131224183545.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins