Featured Research

from universities, journals, and other organizations

Researchers discover molecule behind the benefits of exercise

Date:
January 7, 2014
Source:
Cell Press
Summary:
While it's clear that exercise can improve health and longevity, the changes that occur in the body to facilitate these benefits are less clear. Now researchers have discovered a molecule that is produced during exercise and contributes to the beneficial effects of exercise on metabolism.

While it's clear that exercise can improve health and longevity, the changes that occur in the body to facilitate these benefits are less clear. Now researchers publishing in the January issue of Cell Press journal Cell Metabolism have discovered a molecule that is produced during exercise and contributes to the beneficial effects of exercise on metabolism.

"Our finding bolsters the underlying notion that signals generated in one organ -- such as exercising muscle -- are released into the circulation and influence other tissues such as fat cells and liver," says senior author Dr. Robert Gerszten, of the Cardiology Division and Cardiovascular Research Center at Massachusetts General Hospital, Harvard Medical School.

Seminal studies by the Spiegelman laboratory, which collaborated on this study, have demonstrated that a protein called PGC-1∝ regulates metabolic genes in muscle and contributes to the response of muscle to exercise, but how the PGC-1∝-mediated response to exercise in muscle conveys signals to other tissues is unclear. Through experiments conducted in cells and mice, Gerszten and his colleagues forced the expression of PGC-1∝ in muscle cells and then looked for metabolites that were secreted from the cells. They identified β-aminoisobutyric acid (BAIBA) as one such metabolite and found that it increased fat cells' expression of genes that are involved with burning calories. It also decreased weight gain and helped balance blood sugar levels in mice.

Analyses done in human exercise studies and participants in the Framingham Heart Study revealed that BAIBA levels rise during exercise and are inversely associated with metabolic risk factors. Specifically, BAIBA levels were inversely correlated with fasting blood sugar levels, insulin, triglycerides, and total cholesterol. In addition, there was a trend toward an inverse association with body mass index.

The findings suggest that BAIBA may contribute to exercise-induced protection from metabolic diseases. "Manipulating BAIBA -- or the enzymes that generate BAIBA -- may have therapeutic potential," says Gerszten. "Burning fat is likely to impact multiple aspects of metabolic health related to diabetes, heart disease, and other conditions."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Roberts et al. Beta-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic Beta-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors. Cell Metabolism, January 2014

Cite This Page:

Cell Press. "Researchers discover molecule behind the benefits of exercise." ScienceDaily. ScienceDaily, 7 January 2014. <www.sciencedaily.com/releases/2014/01/140107135757.htm>.
Cell Press. (2014, January 7). Researchers discover molecule behind the benefits of exercise. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2014/01/140107135757.htm
Cell Press. "Researchers discover molecule behind the benefits of exercise." ScienceDaily. www.sciencedaily.com/releases/2014/01/140107135757.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins