Featured Research

from universities, journals, and other organizations

Researchers discover molecule behind the benefits of exercise

Date:
January 7, 2014
Source:
Cell Press
Summary:
While it's clear that exercise can improve health and longevity, the changes that occur in the body to facilitate these benefits are less clear. Now researchers have discovered a molecule that is produced during exercise and contributes to the beneficial effects of exercise on metabolism.

While it's clear that exercise can improve health and longevity, the changes that occur in the body to facilitate these benefits are less clear. Now researchers publishing in the January issue of Cell Press journal Cell Metabolism have discovered a molecule that is produced during exercise and contributes to the beneficial effects of exercise on metabolism.

"Our finding bolsters the underlying notion that signals generated in one organ -- such as exercising muscle -- are released into the circulation and influence other tissues such as fat cells and liver," says senior author Dr. Robert Gerszten, of the Cardiology Division and Cardiovascular Research Center at Massachusetts General Hospital, Harvard Medical School.

Seminal studies by the Spiegelman laboratory, which collaborated on this study, have demonstrated that a protein called PGC-1∝ regulates metabolic genes in muscle and contributes to the response of muscle to exercise, but how the PGC-1∝-mediated response to exercise in muscle conveys signals to other tissues is unclear. Through experiments conducted in cells and mice, Gerszten and his colleagues forced the expression of PGC-1∝ in muscle cells and then looked for metabolites that were secreted from the cells. They identified β-aminoisobutyric acid (BAIBA) as one such metabolite and found that it increased fat cells' expression of genes that are involved with burning calories. It also decreased weight gain and helped balance blood sugar levels in mice.

Analyses done in human exercise studies and participants in the Framingham Heart Study revealed that BAIBA levels rise during exercise and are inversely associated with metabolic risk factors. Specifically, BAIBA levels were inversely correlated with fasting blood sugar levels, insulin, triglycerides, and total cholesterol. In addition, there was a trend toward an inverse association with body mass index.

The findings suggest that BAIBA may contribute to exercise-induced protection from metabolic diseases. "Manipulating BAIBA -- or the enzymes that generate BAIBA -- may have therapeutic potential," says Gerszten. "Burning fat is likely to impact multiple aspects of metabolic health related to diabetes, heart disease, and other conditions."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Roberts et al. Beta-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic Beta-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors. Cell Metabolism, January 2014

Cite This Page:

Cell Press. "Researchers discover molecule behind the benefits of exercise." ScienceDaily. ScienceDaily, 7 January 2014. <www.sciencedaily.com/releases/2014/01/140107135757.htm>.
Cell Press. (2014, January 7). Researchers discover molecule behind the benefits of exercise. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2014/01/140107135757.htm
Cell Press. "Researchers discover molecule behind the benefits of exercise." ScienceDaily. www.sciencedaily.com/releases/2014/01/140107135757.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins