Featured Research

from universities, journals, and other organizations

Evidence of harmful effect of bisphenol A-based plastics

Date:
January 10, 2014
Source:
Ruhr-Universitaet-Bochum
Summary:
Bisphenol A impairs the function of proteins that are vital for growth processes in cells. The substance, BPA for short, is contained in many plastic products and is suspected of being hazardous to health. To date, it had been assumed that bisphenol A produces a harmful effect by binding to hormone receptors. A chemist and biochemist team has discovered that the substance also affects the so-called small GTPases.

Bisphenol A binds to the switch protein K-Ras, which is vital for cell growth processes and plays a role in tumourigenesis.
Credit: RUB, Diagram: Miriam Schöpel

Bisphenol A impairs the function of proteins that are vital for growth processes in cells. This finding has been reported by researchers from the Ruhr-Universität Bochum and the University of Wuppertal. The substance, short BPA, is contained in many plastic products and is suspected of being hazardous to health. To date, it had been assumed that bisphenol A produces a harmful effect by binding to hormone receptors. The chemist and biochemist team has discovered that the substance also affects the so-called small GTPases. They published their findings in the Journal of Medicinal Chemistry.

Related Articles


Complex mechanism of action

"Our research provides further evidence that the physiological effects of bisphenol A may be even more complex than previously assumed," says Prof Dr Raphael Stoll, head of Biomolecular Spectroscopy at the Ruhr-Universität. "However, we have also discovered other related compounds that indicate which path the future development of pharmaceutically effective substances against GTPase-mediated tumours may take," adds synthetic chemist Prof Dr Jürgen Scherkenbeck from Wuppertal.

Bisphenol A impairs the function of GTPases

Small GTPases are enzymes that occur in two states within the cell: in the active form when bound to the GTP molecule; and in the inactive form when bound to GDP, a lower-energy form of GTP. These switch proteins are crucial for transmitting signals within the cell. The researchers have demonstrated that bisphenol A binds to two different small GTPases, K-Ras and H-Ras, thereby preventing the exchange of GDP for GTP. The non-profit organisation German Cancer Aid (Deutsche Krebshilfe e. V.) has financed the project since 2011.

Bisphenol A is a suspected health hazard

Various organisations have pointed out that bisphenol A may be hazardous to health: the Federal Institute for Risk Assessment (Bundesinstitut für Risikoforschung), the European Food Safety Authority, the US Food and Drug Administration (FDA), the US National Institutes of Health (NIH) and the US-American Breast Cancer Foundation. However, those organisations have not yet provided a final assessment of the substance's hazardous potential. Nevertheless, the European Commission banned the use of bisphenol A in the manufacture of baby bottles in 2011. Academic studies indicate that the substance may increase the risk of cardiovascular diseases, breast and prostate cancer as well as neuronal diseases. The researchers therefore recommend a restriction of bisphenol A-based plastic containers for food products.


Story Source:

The above story is based on materials provided by Ruhr-Universitaet-Bochum. Note: Materials may be edited for content and length.


Journal Reference:

  1. Miriam Schöpel, Katharina F. G. Jockers, Peter M. Düppe, Jasmin Autzen, Veena N. Potheraveedu, Semra Ince, King Tuo Yip, Rolf Heumann, Christian Herrmann, Jürgen Scherkenbeck, Raphael Stoll. Bisphenol A Binds to Ras Proteins and Competes with Guanine Nucleotide Exchange: Implications for GTPase-Selective Antagonists. Journal of Medicinal Chemistry, 2013; 56 (23): 9664 DOI: 10.1021/jm401291q

Cite This Page:

Ruhr-Universitaet-Bochum. "Evidence of harmful effect of bisphenol A-based plastics." ScienceDaily. ScienceDaily, 10 January 2014. <www.sciencedaily.com/releases/2014/01/140110102629.htm>.
Ruhr-Universitaet-Bochum. (2014, January 10). Evidence of harmful effect of bisphenol A-based plastics. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2014/01/140110102629.htm
Ruhr-Universitaet-Bochum. "Evidence of harmful effect of bisphenol A-based plastics." ScienceDaily. www.sciencedaily.com/releases/2014/01/140110102629.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins