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Important discovery for diagnosis of genetic diseases

Date:
January 16, 2014
Source:
Institut de recherches cliniques de Montreal
Summary:
A new study shows the importance of the chromatin architecture in controlling the activity of genes, especially those required for proper embryonic development. This discovery could have a significant impact on the diagnosis of genetic diseases.

A study conducted by Marie Kmita's team at the IRCM, in collaboration with Josιe Dostie at McGill University, shows the importance of the chromatin architecture in controlling the activity of genes, especially those required for proper embryonic development. This discovery, recently published in the scientific journal PLOS Genetics, could have a significant impact on the diagnosis of genetic diseases.

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Each cell in the body contains a person's genetic information in the form of DNA molecules, wrapped around structures called nucleosomes. Together, the DNA and nucleosomes form the chromatin, which is the main component of chromosomes.

"Our work shows that the regulation of the activity of genes controlling embryonic development is linked to the three-dimensional organization of the chromatin," explains Dr. Kmita, Director of the Genetics and Development research unit at the IRCM. "In fact, this chromatin architecture, which varies according to the cell type, generates specific contacts between sequences of regulatory DNA and the genes they regulate."

To date, studying the causes of genetic diseases is mainly achieved through DNA sequencing and the analysis of gene sequences. However, the cause of such diseases could just as well be an anomaly in the DNA sequences that control the genes.

"It is now possible to identify regulatory DNA that controls a given gene," adds Dr. Kmita. "Our discovery paves the way for studying the mechanisms that control the architecture of chromatin, which should have a significant impact on identifying the causes and diagnosing genetic diseases."

The IRCM researchers' scientific breakthrough could have an impact on a large number of genetic diseases, including those associated with the Hox genes studied by Dr. Kmita, such as synpolydactyly (a congenital malformation characterized by the fusion of digits and the production of additional digits) and the hand-foot-genital syndrome (a genetic disease characterized by limb malformations and urogenital defects).


Story Source:

The above story is based on materials provided by Institut de recherches cliniques de Montreal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Soizik Berlivet, Denis Paquette, Annie Dumouchel, David Langlais, Josιe Dostie, Marie Kmita. Clustering of Tissue-Specific Sub-TADs Accompanies the Regulation of HoxA Genes in Developing Limbs. PLoS Genetics, 2013; 9 (12): e1004018 DOI: 10.1371/journal.pgen.1004018

Cite This Page:

Institut de recherches cliniques de Montreal. "Important discovery for diagnosis of genetic diseases." ScienceDaily. ScienceDaily, 16 January 2014. <www.sciencedaily.com/releases/2014/01/140116113512.htm>.
Institut de recherches cliniques de Montreal. (2014, January 16). Important discovery for diagnosis of genetic diseases. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2014/01/140116113512.htm
Institut de recherches cliniques de Montreal. "Important discovery for diagnosis of genetic diseases." ScienceDaily. www.sciencedaily.com/releases/2014/01/140116113512.htm (accessed April 1, 2015).

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