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Drugs cut need for surgery for Crohn's disease patients by more than half

Date:
January 28, 2014
Source:
University of St George's London
Summary:
The requirement of bowel surgery is dramatically reduced by up to 60 percent in patients who develop Crohn's disease if they receive prolonged treatment with drugs called thiopurines, says a new study.

The requirement of bowel surgery is dramatically reduced by up to 60% in patients who develop Crohn's disease if they receive prolonged treatment with drugs called thiopurines, says a new study.

Crohn's affects more than quarter-of-a-million people in the UK leading to an inflamed intestine.

Researchers from St George's, University of London, St George's Hospital, London and Imperial College, London, monitored more than 5,000 patients in the UK living with Crohn's disease for more than 20 years and looked at the effect of thiopurine drugs that suppress inflammation in the gut.

Gastroenterologist Dr Richard Pollok, an honorary senior lecturer at St George's, University of London, said "Our discovery is timely since new guidelines from the USA have played down the benefits of these drugs in favor of newer agents.

"A year of treatment with the newer 'biologics', which are administered by injection, cost about 10,000 more compared to thiopurines.

"We try to avoid surgery but some patients face multiple procedures because the disease can flare up again particularly where the intestine has been rejoined.

"The fact that thiopurines can cut the need for surgical intervention and remain affordable is good news for patients and the NHS."

They found patients taking thiopurines, such as Azathioprine, for more than 12 months had a 60% reduction within the first 5 years of diagnosis.

Thiopurines have been used in the treatment of inflammatory bowel conditions like Crohn's disease since the 1970s but their long-term benefits have just come to light.

There has been a major increase in the number of patients who receive these drugs in the past decade and rates of surgery in patients with this condition have dropped, partly as a result of these and other treatments.

But up to a quarter of patients still go on to have their first corrective surgery to remove the worst affected areas within 5 years of being diagnosed.

The study was published in the American Journal of Gastroenterology.


Story Source:

The above story is based on materials provided by University of St George's London. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sukhdev Chatu, Sonia Saxena, Venkataraman Subramanian, Vasa Curcin, Ghasem Yadegarfar, Laura Gunn, Azeem Majeed, Richard C G Pollok. The Impact of Timing and Duration of Thiopurine Treatment on First Intestinal Resection in Crohn's Disease: National UK Population-Based Study 1989–2010. The American Journal of Gastroenterology, 2014; DOI: 10.1038/ajg.2013.462

Cite This Page:

University of St George's London. "Drugs cut need for surgery for Crohn's disease patients by more than half." ScienceDaily. ScienceDaily, 28 January 2014. <www.sciencedaily.com/releases/2014/01/140128094625.htm>.
University of St George's London. (2014, January 28). Drugs cut need for surgery for Crohn's disease patients by more than half. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2014/01/140128094625.htm
University of St George's London. "Drugs cut need for surgery for Crohn's disease patients by more than half." ScienceDaily. www.sciencedaily.com/releases/2014/01/140128094625.htm (accessed April 17, 2014).

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