Featured Research

from universities, journals, and other organizations

Vitamin A used in acne medicines may help autoimmune, transplant patients

Date:
January 30, 2014
Source:
Federation of American Societies for Experimental Biology
Summary:
The same form of Vitamin A used by teenagers to combat acne might offer benefits that are more than skin deep. That's because an international team of researchers have found that it may also help keep the immune system under control for people with autoimmune disorders or those who have received transplants.

The same form of Vitamin A used by teenagers to combat acne might offer benefits that are more than skin deep. That's because an international team of researchers have found that it may also help keep the immune system under control for people with autoimmune disorders or those who have received transplants. This finding was published in the February 2014 issue of the Journal of Leukocyte Biology.

"The results will help us to use the different protocol of Treg induction for clinical therapy in autoimmune diseases and organ transplantation protection,'" said Song Guo Zheng, M.D., Ph.D., a Professor of Medicine and leading author involved in the work from the Department of Medicine, Autoimmunity Research Center at Penn State University Hershey College of Medicine, in Hershey, Pennsylvania.

To make this discovery, scientists used cells isolated from mice and humans to conduct a head-to-head comparison of the role of all-trans retinoid acid (ATRA) on CD4+ and CD8+ Treg cell development. While ATRA significantly promoted CD4+Foxp3+Treg development and function in mice and humans, it did not boost the differentiation and function of CD8+Foxp3+Treg. On the contrary, ATRA interfered with the differentiation and function of human CD8+Foxp3+Treg. This suggests that ATRA-treated CD4+Treg is superior to ATRA-treated CD8+Treg for the treatment of autoimmune disease and organ transplantation. This lays the groundwork for the potential development of specific Treg subsets to combat specific autoimmune diseases and complications.

"The great thing about this discovery is that we already have a strong foundation of clinical use of this form of Vitamin A and know that it is well-tolerated by people," said E. John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "These findings are a great example of the ability to exploit currently used drugs and our growing molecular and cellular understanding of the immune system. Such approaches represent exactly the kind of merging of basic science and clinical medicine that defines translational research."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Ma, Y. Liu, Y. Li, J. Gu, J. Liu, J. Tang, J. Wang, B. Ryffel, Y. Shen, D. Brand, Z. Liu, S. G. Zheng. Differential role of all-trans retinoic acid in promoting the development of CD4 and CD8 regulatory T cells. Journal of Leukocyte Biology, 2013; 95 (2): 275 DOI: 10.1189/jlb.0513297

Cite This Page:

Federation of American Societies for Experimental Biology. "Vitamin A used in acne medicines may help autoimmune, transplant patients." ScienceDaily. ScienceDaily, 30 January 2014. <www.sciencedaily.com/releases/2014/01/140130102152.htm>.
Federation of American Societies for Experimental Biology. (2014, January 30). Vitamin A used in acne medicines may help autoimmune, transplant patients. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2014/01/140130102152.htm
Federation of American Societies for Experimental Biology. "Vitamin A used in acne medicines may help autoimmune, transplant patients." ScienceDaily. www.sciencedaily.com/releases/2014/01/140130102152.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins