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Exercise targets cellular powerhouses to improve heart function

Date:
February 12, 2014
Source:
American Chemical Society
Summary:
Whether lifting weights in a gym or just walking around the block, exercise has many benefits, such as helping people lose weight and build stronger muscles. Some studies suggest that it may reduce the risk of developing cancer and other diseases. Researchers now report that moderate, long-term physical activity appears to improve cardiovascular health in mice by targeting the heart cells' powerhouses -- the mitochondria.

Whether lifting weights in a gym or just walking around the block, exercise has many benefits, such as helping people lose weight and build stronger muscles. Some studies suggest that it may reduce the risk of developing cancer and other diseases. Researchers now report in ACS' Journal of Proteome Research that moderate, long-term physical activity appears to improve cardiovascular health in mice by targeting the heart cells' powerhouses -- the mitochondria.

Eduard Sabidó, Francisco Amado and colleagues explain that despite the well-documented benefits of exercise, the exact way that it helps the heart is not well understood. Sure, it helps strengthen the heart muscle so it can pump more blood throughout the body more efficiently. And people who get off the couch and exercise regularly have a reduced risk of developing heart problems and cardiovascular disease. One estimate even claims that 250,000 deaths every year in the U.S. are at least partially due to a lack of exercise. But how this all happens in the body at the molecular level has perplexed researchers -- until now.

The team found that laboratory mice (stand-ins for humans) that exercised for 54 weeks on a treadmill-running regimen had higher levels of certain proteins in the mitochondria of their heart cells than mice that did not exercise. Mitochondria produce energy for the body's cells. In particular, they identified two proteins, kinases called RAF and p38, that "seem to trigger the beneficial cardiovascular effects of lifelong exercise training," they say.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rita Ferreira, Rui Vitorino, Anna Isabel Padrao, Guadalupe Espadas, Francesco Mattia Mancuso, Daniel Moreira-Gonçalves, Gonçalo Castro-Sousa, Tiago Henriques-Coelho, Paula A Oliveira, Antonio S Barros, José Alberto Duarte, Eduard Sabidó, Francisco Amado. Lifelong exercise training modulates cardiac mitochondrial phosphoproteome in rats. Journal of Proteome Research, 2014; 140128075751007 DOI: 10.1021/pr4011926

Cite This Page:

American Chemical Society. "Exercise targets cellular powerhouses to improve heart function." ScienceDaily. ScienceDaily, 12 February 2014. <www.sciencedaily.com/releases/2014/02/140212112749.htm>.
American Chemical Society. (2014, February 12). Exercise targets cellular powerhouses to improve heart function. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2014/02/140212112749.htm
American Chemical Society. "Exercise targets cellular powerhouses to improve heart function." ScienceDaily. www.sciencedaily.com/releases/2014/02/140212112749.htm (accessed September 21, 2014).

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