Featured Research

from universities, journals, and other organizations

Exercise targets cellular powerhouses to improve heart function

Date:
February 12, 2014
Source:
American Chemical Society
Summary:
Whether lifting weights in a gym or just walking around the block, exercise has many benefits, such as helping people lose weight and build stronger muscles. Some studies suggest that it may reduce the risk of developing cancer and other diseases. Researchers now report that moderate, long-term physical activity appears to improve cardiovascular health in mice by targeting the heart cells' powerhouses -- the mitochondria.

Whether lifting weights in a gym or just walking around the block, exercise has many benefits, such as helping people lose weight and build stronger muscles. Some studies suggest that it may reduce the risk of developing cancer and other diseases. Researchers now report in ACS' Journal of Proteome Research that moderate, long-term physical activity appears to improve cardiovascular health in mice by targeting the heart cells' powerhouses -- the mitochondria.

Related Articles


Eduard Sabidó, Francisco Amado and colleagues explain that despite the well-documented benefits of exercise, the exact way that it helps the heart is not well understood. Sure, it helps strengthen the heart muscle so it can pump more blood throughout the body more efficiently. And people who get off the couch and exercise regularly have a reduced risk of developing heart problems and cardiovascular disease. One estimate even claims that 250,000 deaths every year in the U.S. are at least partially due to a lack of exercise. But how this all happens in the body at the molecular level has perplexed researchers -- until now.

The team found that laboratory mice (stand-ins for humans) that exercised for 54 weeks on a treadmill-running regimen had higher levels of certain proteins in the mitochondria of their heart cells than mice that did not exercise. Mitochondria produce energy for the body's cells. In particular, they identified two proteins, kinases called RAF and p38, that "seem to trigger the beneficial cardiovascular effects of lifelong exercise training," they say.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rita Ferreira, Rui Vitorino, Anna Isabel Padrao, Guadalupe Espadas, Francesco Mattia Mancuso, Daniel Moreira-Gonçalves, Gonçalo Castro-Sousa, Tiago Henriques-Coelho, Paula A Oliveira, Antonio S Barros, José Alberto Duarte, Eduard Sabidó, Francisco Amado. Lifelong exercise training modulates cardiac mitochondrial phosphoproteome in rats. Journal of Proteome Research, 2014; 140128075751007 DOI: 10.1021/pr4011926

Cite This Page:

American Chemical Society. "Exercise targets cellular powerhouses to improve heart function." ScienceDaily. ScienceDaily, 12 February 2014. <www.sciencedaily.com/releases/2014/02/140212112749.htm>.
American Chemical Society. (2014, February 12). Exercise targets cellular powerhouses to improve heart function. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2014/02/140212112749.htm
American Chemical Society. "Exercise targets cellular powerhouses to improve heart function." ScienceDaily. www.sciencedaily.com/releases/2014/02/140212112749.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) — Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) — If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) — GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) — How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins