Featured Research

from universities, journals, and other organizations

More intensive radiotherapy better than less for localized prostate cancer

Date:
February 25, 2014
Source:
Institute of Cancer Research
Summary:
A radiotherapy regime involving higher doses of radiation is a better option than having lower doses for men with localized prostate cancer, the 10-year results of the largest trial of its kind have shown. Having 37 rounds, or fractions, of radiotherapy at 74 Gray (Gy) -- compared with 32 fractions at 64 Gy -- controlled the disease more effectively and reduced the chance that men would need follow-up hormone-deprivation therapy, which can have long-term side-effects.

A radiotherapy regime involving higher doses of radiation is a better option than having lower doses for men with localized prostate cancer, the 10-year results of the largest trial of its kind have shown.

Having 37 rounds, or fractions, of radiotherapy at 74 Gray (Gy) -- compared with 32 fractions at 64 Gy -- controlled the disease more effectively and reduced the chance that men would need follow-up hormone-deprivation therapy, which can have long-term side-effects.

The findings, published in The Lancet Oncology, come from the major RT01 phase III trial. The trial was led by Professor David Dearnaley, Professor of Uro-Oncology at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust, and was funded and conducted by the Medical Research Council Clinical Trials Unit at UCL. The study also involved several leading clinical research centres in the UK, New Zealand and Australia.

The study also demonstrated the overall effectiveness of radiotherapy for men with localized disease. Almost three quarters of men treated with either the more or less intensive radiotherapy regimes were still alive after 10 years.

Set up in 1998, the trial split 843 men with localized prostate cancer into two groups to compare the two doses of radiotherapy. Some 421 men had the less and 422 the more intensive treatment regimes. Both groups also had standard hormone-deprivation treatment alongside their radiotherapy.

The five-year results of the trial have previously shown the benefits of dose-escalated radiotherapy, and played an influential role in changing NICE guidance to recommend it in prostate cancer. Dose escalation is now the norm for localized prostate cancer in the UK.

The new 10-year results further strengthen the evidence for choosing dose-escalation radiotherapy, as well as showing the long-term benefits of the treatment.

After 10 years, 55 per cent of men on the 37-fraction regime, compared with 43 per cent of men on the 32-fraction regime, had survived without their disease progressing into a more hazardous form, as measured by the standard prostate-specific antigen (PSA) test. In each half of the study, 71 per cent of men were alive after 10 years and only 11 per cent had died from prostate cancer.

Men who received the higher dose were more likely to have side-effects associated with radiotherapy, but few men had severe side-effects. Receiving the higher dose reduced the need for follow-up hormone treatment, which also carries a risk of side-effects.

The trial did not show that men given dose-escalated radiotherapy live longer, but both groups of men lived much longer than expected. Almost three quarters of all the men in the study were still alive after 10 years, and of the 236 men who had died since treatment, only 91 had died of prostate cancer.

Professor Dearnaley said: "Our study has proved that treating men with localized prostate cancer using higher doses of radiotherapy is more effective than a less intensive regime. The dose-escalated regime is safe in the long term, and reduces the chances that a cancer will return and men will require further hormone-deprivation treatment. The side-effects of hormone treatment do need to be balanced against those of the extra radiotherapy doses, but overall our study has shown men are better off after having the escalated regime, as is now the norm in the UK.

"Another key finding to come out of our study is that radiotherapy in general is both a safe and an effective treatment for localized prostate cancer. Almost three quarters of men treated with either the more or less intensive radiotherapy regimes are still alive after 10 years, and of the men who have died, less than half actually died from prostate cancer.

"Further refinements in radiotherapy techniques since our trial began have made treatment even safer and are very important as men with localized prostate cancer have such favourable long-term survival prospects."

Matthew Sydes, Senior Scientist and Statistician at the MRC Clinical Trials Unit at UCL, said: "The RT01 trial has already changed how men with localized prostate cancer are treated. The current NICE guidelines recommend the use of the higher dose of radiotherapy, based on the five-year results of RT01. The trial also helped to develop guidelines on how to limit the radiation that organs near the tumor receive, and helped hospitals across the UK to introduce quality-assured conformal radiotherapy. It is now contributing to biological studies to help better understand the disease and the side-effects of radiotherapy."


Story Source:

The above story is based on materials provided by Institute of Cancer Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. David P Dearnaley, Gordana Jovic, Isabel Syndikus, Vincent Khoo, Richard A Cowan, John D Graham, Edwin G Aird, David Bottomley, Robert A Huddart, Chakiath C Jose, John H L Matthews, Jeremy L Millar, Claire Murphy, J Martin Russell, Christopher D Scrase, Mahesh K B Parmar, Matthew R Sydes. Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial. The Lancet Oncology, 2014; DOI: 10.1016/S1470-2045(14)70040-3

Cite This Page:

Institute of Cancer Research. "More intensive radiotherapy better than less for localized prostate cancer." ScienceDaily. ScienceDaily, 25 February 2014. <www.sciencedaily.com/releases/2014/02/140225193410.htm>.
Institute of Cancer Research. (2014, February 25). More intensive radiotherapy better than less for localized prostate cancer. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2014/02/140225193410.htm
Institute of Cancer Research. "More intensive radiotherapy better than less for localized prostate cancer." ScienceDaily. www.sciencedaily.com/releases/2014/02/140225193410.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins