Featured Research

from universities, journals, and other organizations

Type 1 diabetes: Vitamin D deficiency occurs in early stage

Date:
February 27, 2014
Source:
Helmholtz Zentrum München - German Research Center for Environmental Health
Summary:
Low levels of vitamin D are commonly found in people with type 1 diabetes. But even children who have multiple positive islet autoantibodies without manifest type 1 diabetes have lower levels of vitamin D in their blood. This does not appear, however, to influence the progression of the disease from pre-diabetes to diabetes, according to scientists. "Vitamin D deficiency precedes the onset of type 1 diabetes. This may be a consequence of an immune response," one author says. "In the case of prediabetic children, we must therefore be mindful of the risk of vitamin D deficiency and consider recommending vitamin D supplementation at an early stage of type 1 diabetes."

Vitamin D is known as a major regulator of calcium levels and bone metabolism. Furthermore, it also influences the immune system. Previous studies have shown that patients with recently diagnosed type 1 diabetes have significantly lower vitamin D levels.

Related Articles


Scientists from the Institute of Diabetes Research (IDF) and the Helmholtz Zentrum München, a member of the German Center for Diabetes Research (DZD), as well as from the Diabetes Research Group at the Technische Universität München (TUM) examined whether a vitamin D deficiency occurs during an early stage of type 1 diabetes, defined by the presence of multiple diabetes-specific islet autoantibodies. Furthermore they also determined whether vitamin D deficiency influences the progression to type 1 diabetes in children with multiple islet autoantibodies.

Vitamin D deficiency already exists in prediabetes

Children who had not yet developed clinical type 1 diabetes but who have multiple positive autoantibodies in their blood were found to have lower vitamin D levels than children without diabetes-specific autoantibodies. Interestingly, the differences in vitamin D levels were most prevalent in the summer months. These results were obtained from the BABYDIET, BABYDIAB, TEENDIAB and DIMELLI diabetes studies. The team of scientists headed by Jennifer Raab, Dr. Christiane Winkler and Professor Anette-Gabriele Ziegler compared the vitamin D measurements taken from 108 children who were tested positive for islet autoantibodies with 406 children without autoantibodies. Lower vitamin D levels were also found in 244 children who had recently been diagnosed with type 1 diabetes.

Progression of the disease remains unaffected

Prediabetes is defined as the presence of multiple islet autoantibodies. If and when the disease progresses, however, does not seem to be influenced by the vitamin D levels. Within the group of children with positive autoantibodies, a few children quickly developed type 1 diabetes -- however this was independent from their vitamin D levels.

Recommendation of vitamin D supplementation at an early stage of type 1 diabetes may be considered

"Vitamin D deficiency precedes the onset of type 1 diabetes. This may be a consequence of an immune response," Professor Ziegler says. "In the case of prediabetic children, we must therefore be mindful of the risk of vitamin D deficiency and consider recommending vitamin D supplementation at an early stage of type 1 diabetes."


Story Source:

The above story is based on materials provided by Helmholtz Zentrum München - German Research Center for Environmental Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jennifer Raab, Eleni Z. Giannopoulou, Simone Schneider, Katharina Warncke, Miriam Krasmann, Christiane Winkler, Anette-Gabriele Ziegler. Prevalence of vitamin D deficiency in pre-type 1 diabetes and its association with disease progression. Diabetologia, 2014; DOI: 10.1007/s00125-014-3181-4

Cite This Page:

Helmholtz Zentrum München - German Research Center for Environmental Health. "Type 1 diabetes: Vitamin D deficiency occurs in early stage." ScienceDaily. ScienceDaily, 27 February 2014. <www.sciencedaily.com/releases/2014/02/140227115426.htm>.
Helmholtz Zentrum München - German Research Center for Environmental Health. (2014, February 27). Type 1 diabetes: Vitamin D deficiency occurs in early stage. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2014/02/140227115426.htm
Helmholtz Zentrum München - German Research Center for Environmental Health. "Type 1 diabetes: Vitamin D deficiency occurs in early stage." ScienceDaily. www.sciencedaily.com/releases/2014/02/140227115426.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) — An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins