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Antibody-targeted treatment developed for recurrent small-cell lung cancer

Date:
March 3, 2014
Source:
Norris Cotton Cancer Center/Dartmouth-Hitchcock Medical Center
Summary:
An antibody has been found that may be used in future treatments for recurrent small-cell lung cancer, which currently has no effective therapy. The mouse monoclonal antibody they have developed, MAG-1, targets the ProAVP surface marker. When given alone, it significantly slows the growth of tumor xenografts of human recurrent small-cell lung cancer in mice.

Researchers at Norris Cotton Cancer Center have found an antibody that may be used in future treatments for recurrent small-cell lung cancer, which currently has no effective therapy. The mouse monoclonal antibody they have developed, MAG-1, targets the ProAVP surface marker. When given alone, it significantly slows the growth of tumor xenografts of human recurrent small-cell lung cancer in mice.

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The study, "Growth Impairment of Small-Cell Cancer by Targeting Pro-Vasopressin with MAG-1 Antibody," was recently published online in Frontiers in Oncology.

"We are developing methods of antibody-targeted treatment for recurrent small-cell lung cancer," said lead author William G. North, PhD, professor of Physiology at the Geisel School of Medicine at Dartmouth and a member of the Norris Cotton Cancer Center. "Targeting with a humanized MAG-1 can likely be effective, especially when given in combination with chemotherapy, for treating a deadly disease for which there is no effective therapy."

North says his group has already generated a human chimeric form of MAG-1 that is equally effective as mouse MAG-1, and they are now generating a humanized form for use in patients.


Story Source:

The above story is based on materials provided by Norris Cotton Cancer Center/Dartmouth-Hitchcock Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. William G. North, Bernard Cole, Bonnie Akerman, Roy H. L. Pang. Growth Impairment of Small-Cell Cancer by Targeting Pro-Vasopressin with MAG-1 Antibody. Frontiers in Oncology, 2014; 4 DOI: 10.3389/fonc.2014.00016

Cite This Page:

Norris Cotton Cancer Center/Dartmouth-Hitchcock Medical Center. "Antibody-targeted treatment developed for recurrent small-cell lung cancer." ScienceDaily. ScienceDaily, 3 March 2014. <www.sciencedaily.com/releases/2014/03/140303163149.htm>.
Norris Cotton Cancer Center/Dartmouth-Hitchcock Medical Center. (2014, March 3). Antibody-targeted treatment developed for recurrent small-cell lung cancer. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2014/03/140303163149.htm
Norris Cotton Cancer Center/Dartmouth-Hitchcock Medical Center. "Antibody-targeted treatment developed for recurrent small-cell lung cancer." ScienceDaily. www.sciencedaily.com/releases/2014/03/140303163149.htm (accessed March 4, 2015).

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