Featured Research

from universities, journals, and other organizations

Worldwide standard in diagnosing melanoma established

Date:
March 10, 2014
Source:
Moffitt Cancer Center
Summary:
Significant improvements have been made to the diagnostic procedure called sentinel node biopsy for melanoma patients. Sentinel nodes are the first lymph nodes to which cancer cells from a primary tumor like melanoma will spread. In the sentinel node biopsy procedure, a radioactive tracer and a blue-colored dye are injected at or near the melanoma site on the skin and tracked to the first lymph node(s). These sentinel nodes are then surgically removed and analyzed for the presence of cancer cells. If tumor cells are present within the node, the primary tumor has spread and additional lymph nodes may need to be removed and medical treatments tailored accordingly. If tumor cells are not present in the sentinel node, the primary tumor most likely has not spread to lymph nodes or other organs. New research is improving this procedure.

Moffitt Cancer Center researchers have been instrumental in making significant improvements to the diagnostic procedure called sentinel node biopsy for melanoma patients and teaching this procedure to physicians from around the world.

Related Articles


Sentinel nodes are the first lymph nodes to which cancer cells from a primary tumor like melanoma will spread. In the sentinel node biopsy procedure, a radioactive tracer and a blue-colored dye are injected at or near the melanoma site on the skin and tracked to the first lymph node(s). These sentinel nodes are then surgically removed and analyzed for the presence of cancer cells. If tumor cells are present within the node, the primary tumor has spread and additional lymph nodes may need to be removed and medical treatments tailored accordingly. If tumor cells are not present in the sentinel node, the primary tumor most likely has not spread to lymph nodes or other organs.

Sentinel node biopsy reduces the possibility of patients having to undergo extensive lymph node surgery and its associated side effects such as tissue swelling, lymph accumulation at the surgery site, pain, discomfort, and overall decreased quality of life.

"Moffitt played a pioneering role in the development, testing and teaching of sentinel node biopsy, after the procedure was introduced in 1992," said Vernon K. Sondak, M.D., chair of Moffitt's Department of Cutaneous Oncology. "Now, this procedure has become a worldwide standard."

The final results of the Multicenter Selective Lymphadenectomy Trial (MSLT-1) that began in 1994 to assess the benefits of sentinel node biopsy for melanoma patients were recently published in the New England Journal of Medicine (NEJM). Moffitt's Christopher A. Puleo, PA-C, was one of the contributors to the study and is a co-author of the publication.

The article reports data from a 10-year follow-up of 2001 melanoma patients from the landmark MSLT-1 study; preliminary data were first published in the NEJM in 2006. Patients who had sentinel node biopsies had significantly greater 10-year disease-free survival rates than patients who underwent nodal observation. Node-positive patients also had improved 10-year rates of survival without metastasis and melanoma-free survival compared to those whose nodes were found to be positive on the nodal observation arm of the study.


Story Source:

The above story is based on materials provided by Moffitt Cancer Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Donald L. Morton, John F. Thompson, Alistair J. Cochran, Nicola Mozzillo, Omgo E. Nieweg, Daniel F. Roses, Harold J. Hoekstra, Constantine P. Karakousis, Christopher A. Puleo, Brendon J. Coventry, Mohammed Kashani-Sabet, B. Mark Smithers, Eberhard Paul, William G. Kraybill, J. Gregory McKinnon, He-Jing Wang, Robert Elashoff, Mark B. Faries. Final Trial Report of Sentinel-Node Biopsy versus Nodal Observation in Melanoma. New England Journal of Medicine, 2014; 370 (7): 599 DOI: 10.1056/NEJMoa1310460

Cite This Page:

Moffitt Cancer Center. "Worldwide standard in diagnosing melanoma established." ScienceDaily. ScienceDaily, 10 March 2014. <www.sciencedaily.com/releases/2014/03/140310111246.htm>.
Moffitt Cancer Center. (2014, March 10). Worldwide standard in diagnosing melanoma established. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2014/03/140310111246.htm
Moffitt Cancer Center. "Worldwide standard in diagnosing melanoma established." ScienceDaily. www.sciencedaily.com/releases/2014/03/140310111246.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins