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Commonly used pain relievers have added benefit of fighting bacterial infection

Date:
March 13, 2014
Source:
Cell Press
Summary:
Some commonly used drugs that combat aches and pains, fever, and inflammation are also thought to have the ability to kill bacteria. New research reveals that these drugs, better known as nonsteroidal anti-inflammatory drugs, act on bacteria in a way that is fundamentally different from current antibiotics. The discovery could open up new strategies for fighting drug-resistant infections and 'superbugs.'

This image shows nonsteroidal anti-inflammatory drugs bound to bacterial protein.
Credit: Aaron Oakley

Some commonly used drugs that combat aches and pains, fever, and inflammation are also thought to have the ability to kill bacteria. New research appearing online on March 13 in the Cell Press journal Chemistry & Biology reveals that these drugs, better known as NSAIDs, act on bacteria in a way that is fundamentally different from current antibiotics. The discovery could open up new strategies for fighting drug-resistant infections and "superbugs."

"We discovered that some anti-inflammatory drugs used in human and veterinary medicine have weak antibiotic activity and that they exert this secondary activity by preventing bacteria from copying their DNA, which they need to do in order to multiply," explains senior author Dr. Aaron Oakley of the University of Wollongong, in Australia. The researchers analyzed three NSAIDs: bromofenac, carprofen, and vedaprofen. The more commonly known NSAIDs, which include aspirin, ibuprofen, and naproxen, were not tested.

Dr. Oakley and his team identified that anti-inflammatory drugs bind to and inhibit a specific protein in bacteria called the DNA clamp. The DNA clamp, which is conserved across bacterial species, is part of an enzyme that synthesizes DNA molecules from their nucleotide building blocks.

The discovery comes at a time when there is a pressing need for new classes of antibiotics. "The fact that the bacteria-killing effect of the anti-inflammatory drugs is different from conventional drugs means that the NSAIDS could be developed into new kinds of antibiotics that are effective against so-called superbugs," says Dr. Oakley. "This is important because the superbugs have become resistant to many -- and in some cases most -- of the available antibiotics."


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yin et al. DNA Replication is the Target for the Antibacterial Effects of Non-Steroidal Anti-Inflammatory Drugs. Chemistry & Biology, March 2014

Cite This Page:

Cell Press. "Commonly used pain relievers have added benefit of fighting bacterial infection." ScienceDaily. ScienceDaily, 13 March 2014. <www.sciencedaily.com/releases/2014/03/140313123127.htm>.
Cell Press. (2014, March 13). Commonly used pain relievers have added benefit of fighting bacterial infection. ScienceDaily. Retrieved September 3, 2014 from www.sciencedaily.com/releases/2014/03/140313123127.htm
Cell Press. "Commonly used pain relievers have added benefit of fighting bacterial infection." ScienceDaily. www.sciencedaily.com/releases/2014/03/140313123127.htm (accessed September 3, 2014).

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