Featured Research

from universities, journals, and other organizations

New childhood tuberculosis estimates double number previously thought

Date:
March 24, 2014
Source:
Brigham and Women's Hospital
Summary:
Around one million children suffer from tuberculosis annually -- twice the number previously thought to have tuberculosis and three times the number that are diagnosed every year, researchers estimate. In order to obtain these estimates the researchers used several sources of publicly available data and devised a new method to correct for the chronic under-diagnosis that occurs in children, using conventional TB tests which were designed for and work best on adults.

Researchers from Brigham and Women's Hospital (BWH) and Harvard Medical School (HMS) in Boston have estimated that around one million children suffer from tuberculosis (TB) annually -- twice the number previously thought to have tuberculosis and three times the number that are diagnosed every year. The researchers also estimated that around 32,000 children suffer from multidrug-resistant tuberculosis (MDR-TB) annually. These findings are published in The Lancet on March 23, 2014.

"Despite children comprising approximately one quarter of the world's population, there have been no previous estimates of how many suffer from MDR-TB disease," explained Ted Cohen, MD, DrPH, HMS associate professor of Medicine in BWH's Division of Global Health Equity and co-senior author of this study. "Our estimate of the total number of new cases of childhood TB is twice that estimated by the WHO in 2011 and three times the number of child TB cases notified globally each year," said Cohen, who is also associate professor in the Department of Epidemiology at Harvard School of Public Health.

"TB in a child is recognized as a sentinel event; it tells us about ongoing transmission and missed opportunities for prevention," explained Mercedes Becerra, ScD, associate professor of Global Health and Social Medicine at HMS and co-senior author of the study. "Improved estimates are essential so that we can begin to understand the unmet need for pediatric TB treatment."

In order to obtain these estimates the researchers used several sources of publicly available data and devised a new method to correct for the chronic under-diagnosis that occurs in children, using conventional TB tests which were designed for and work best on adults. The researchers used two models to estimate both the regional and global annual incidence of MDR-TB in children. Their findings indicate that around 1,000,000 children developed TB disease in 2010 and of those, 32,000 had MDR-TB.

These findings underscore the urgent need for expanded investment in the global response to TB and MDR-TB in children. "Our findings demonstrate that there is a need for improved methods for collecting data on childhood TB. A good starting place would be improved diagnostic methods for children and more systematic collection of information on how many children are suffering with this disease," explained Helen Jenkins, PhD, HMS instructor in BWH's Division of Global Health Equity and lead statistician on the project.


Story Source:

The above story is based on materials provided by Brigham and Women's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Helen E Jenkins, Arielle W Tolman, Courtney M Yuen, Jonathan B Parr, Salmaan Keshavjee, Carlos M Pιrez-Vιlez, Marcello Pagano, Mercedes C Becerra, Ted Cohen. Incidence of multidrug-resistant tuberculosis disease in children: systematic review and global estimates. The Lancet, 2014; DOI: 10.1016/S0140-6736(14)60195-1

Cite This Page:

Brigham and Women's Hospital. "New childhood tuberculosis estimates double number previously thought." ScienceDaily. ScienceDaily, 24 March 2014. <www.sciencedaily.com/releases/2014/03/140324090435.htm>.
Brigham and Women's Hospital. (2014, March 24). New childhood tuberculosis estimates double number previously thought. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2014/03/140324090435.htm
Brigham and Women's Hospital. "New childhood tuberculosis estimates double number previously thought." ScienceDaily. www.sciencedaily.com/releases/2014/03/140324090435.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) — West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) — A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) — Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins