Featured Research

from universities, journals, and other organizations

Simple changes in ICU can help heart attack patients: Study

Date:
April 1, 2014
Source:
University of Guelph
Summary:
To improve recovery for heart attack patients, hospitals should maintain normal day and night cycles for those patients during the first few days after the attack, say researchers. The new study shows for the first time that interrupting diurnal rhythms impairs healing immediately after a heart attack.

To improve recovery for heart attack patients, hospitals should maintain normal day and night cycles for those patients during the first few days after the attack, say University of Guelph researchers.

Their new study shows for the first time that interrupting diurnal rhythms impairs healing immediately after a heart attack, said Prof. Tami Martino of the Department of Biomedical Sciences.

Researchers already knew that circadian rhythms, or day-night cycles, can affect timing of a heart attack. This is the first study to show the importance of circadian rhythms during the few days after an attack.

The study led by U of G scientists appears this week online in Circulation Research journal.

"We have devised a simple way to better practise medicine to improve the outcome from heart attacks by considering normal circadian rhythms," she said.

She and PhD student Faisal Alibhai conducted the study with clinician collaborators, who are already looking at ways to use the results to change practices in intensive care units (ICU). "It has an immediate life application," said Martino.

Hospital ICUs are busy places at night, with noise, light, nursing and medical procedures, and other interruptions that disturb acutely ill patients.

The team induced heart attacks in mice, and then compared rodents held under normal light and dark cycles with others whose diurnal cycles were disrupted for five days after the attacks.

Early heart repair and remodeling were impaired in the disrupted mice. Diurnal disruptions interfered with their normal inflammatory and immune responses crucial for scar formation and healing.

"These mice were likely to go more quickly to heart failure," said Martino. "Disrupting circadian rhythms for the first few days after a heart attack worsens the disease outcome."

The first five days after a heart attack are crucial for proper scar formation, removal of dead tissue, proliferation of new cells and growth of blood vessels in the heart.


Story Source:

The above story is based on materials provided by University of Guelph. Note: Materials may be edited for content and length.


Journal Reference:

  1. F. J. Alibhai, E. V. Tsimakouridze, N. Chinnappareddy, D. C. Wright, F. Billia, L. O'Sullivan, W. G. Pyle, M. J. Sole, T. A. Martino. Short Term Disruption of Diurnal Rhythms Following Murine Myocardial Infarction Adversely Affects Long Term Myocardial Structure and Function. Circulation Research, 2014; DOI: 10.1161/CIRCRESAHA.114.302995

Cite This Page:

University of Guelph. "Simple changes in ICU can help heart attack patients: Study." ScienceDaily. ScienceDaily, 1 April 2014. <www.sciencedaily.com/releases/2014/04/140401102920.htm>.
University of Guelph. (2014, April 1). Simple changes in ICU can help heart attack patients: Study. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2014/04/140401102920.htm
University of Guelph. "Simple changes in ICU can help heart attack patients: Study." ScienceDaily. www.sciencedaily.com/releases/2014/04/140401102920.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins