Featured Research

from universities, journals, and other organizations

With no hope of kidney match, woman receives successful transplant

Date:
April 3, 2014
Source:
University of Illinois at Chicago
Summary:
An orphan drug renders destructive antibodies harmless, allowing physicians to perform a successful kidney transplant in a highly positive crossmatch patient. In some cases, a transplant can be performed even if a donor and recipient are not compatible. The patient must undergo several days of therapeutic plasma exchanges, or plasmapheresis, to remove antibodies from the blood. The patient is then given an infusion of immune globulin to mask the harmful antibodies along with a drug to suppress the immune system.

Kimberly Gosell and Dr. Enrico Benedetti, professor and head of surgery at the University of Illinois Hospital
Credit: Josh Clark/UIC Photo Services

Kimberly Gosell had more than 40 friends and family who were willing to donate a kidney to restore her health -- and an immune system primed with harmful antibodies that would damage a new organ from any of them.

The 44-year-old mother of two teens had developed high levels of antibodies that attack foreign tissue, causing a positive crossmatch, which made finding a compatible donor for her nearly impossible.

To combat the destructive antibodies and render them harmless so she could receive a new kidney, her physicians at the University of Illinois Hospital and Health System gave Gosell an orphan drug that was shown -- in small studies -- to inhibit antibody-mediated rejection.

In some cases, a transplant can be performed even if a donor and recipient are not compatible. The patient must undergo several days of therapeutic plasma exchanges, or plasmapheresis, to remove antibodies from the blood. The patient is then given an infusion of immune globulin to mask the harmful antibodies along with a drug to suppress the immune system.

When antibodies against the donor's white blood cells decrease to very low levels and the crossmatch becomes negative, the patient is ready for transplant.

Kimberly Gosell and Dr. Enrico Benedetti Kimberly Gosell and Dr. Enrico Benedetti, professor and head of surgery at the University of Illinois Hospital In Gosell's case, attempts to achieve a negative crossmatch with plasmapheresis were unsuccessful.

The orphan drug she received, Eculizumab, is a monoclonal antibody capable of blocking activation of the body's complement system, a group of proteins in the blood that are ultimately responsible for the damage to the transplanted organ. In previous studies, kidney transplant patients with a positive crossmatch were treated with plasmapheresis to remove antibodies from the blood until a negative cross-match was achieved. Then Eculizumab was used to reduce the rate of antibody-mediated rejection.

"This was her only hope for a transplant," said Dr. Enrico Benedetti, professor and head of surgery at the University of Illinois Hospital, who believes this is the first time that the drug has been used in a patient with a persistently highly positive crossmatch. The transplant team that performed the procedure also included Dr. Jose Oberholzer.

Gosell received an injection of Eculizumab a few hours before receiving one of her father's kidneys on Feb. 13. She will continue to have periodic injections of the drug for up to several weeks following the transplant.

The drug "may allow successful kidney transplantation even in patients who are usually excluded from transplant," said Benedetti.

"We would not have dared to do the transplant in our center without the protection of the drug," he said.

Gosell, a UIC employee, received a previous living-donor kidney from her cousin in 2008. That transplant was unsuccessful, and she spent the last two-and-a-half years on dialysis in declining health.

"I am humbled and grateful for my dad," said Gosell.

She says she named her new kidney "Faith."

Gosell has been supported by wonderful friends and family and shares her journey with them on Facebook.

In one of her recent posts she writes, "Notes from Kidneyland -- Faith and I are coexisting in a beautiful fashion. She is quite the lifesaver!"


Story Source:

The above story is based on materials provided by University of Illinois at Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University of Illinois at Chicago. "With no hope of kidney match, woman receives successful transplant." ScienceDaily. ScienceDaily, 3 April 2014. <www.sciencedaily.com/releases/2014/04/140403131740.htm>.
University of Illinois at Chicago. (2014, April 3). With no hope of kidney match, woman receives successful transplant. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2014/04/140403131740.htm
University of Illinois at Chicago. "With no hope of kidney match, woman receives successful transplant." ScienceDaily. www.sciencedaily.com/releases/2014/04/140403131740.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins