Featured Research

from universities, journals, and other organizations

Higher total folate intake may be associated with lower risk of exfoliation glaucoma

Date:
April 3, 2014
Source:
Massachusetts Eye and Ear Infirmary
Summary:
Researchers observed that higher total folate intake was associated with a lower risk for exfoliation glaucoma/suspected exfoliation glaucoma (SEG), supporting a possible causal role of homocysteine in EG/SEG. Elevated homocysteine, which may enhance exfoliation material formation, is one possible risk factor that has received significant research attention. Research studies demonstrate that high intake of vitamin B6, vitamin B12 and folate is associated with lower homocysteine levels.

Exfoliation glaucoma (EG), caused by exfoliation syndrome, a condition in which white clumps of fibrillar material form in the eye, is the most common cause of secondary open-angle glaucoma and a leading cause of blindness and visual impairment. Effective strategies for preventing this disease are lacking.

Elevated homocysteine, which may enhance exfoliation material formation, is one possible risk factor that has received significant research attention. Research studies demonstrate that high intake of vitamin B6, vitamin B12 and folate is associated with lower homocysteine levels. A prospective study from Massachusetts Eye and Ear, Brigham and Women's Hospital (BWH) / Harvard Medical School (HMS), and Harvard School of Public Health (HSPH) set out to evaluate the association between the intake of these vitamins and EG.

The researchers designed a prospective cohort study using more than 20 years of follow-up data from the Nurses' Health Study (all female registered nurses) and the Health Professionals Follow-up Study (all male health professionals) from June 1, 1980 to May 31, 2010 (Nurses' Health Study) and Jan. 1, 1986 to Dec. 31, 2010 (Health Professionals Follow-up Study). They observed that higher total folate intake was associated with a lower risk for EG/suspected exfoliation glaucoma (SEG), supporting a possible causal role of homocysteine in EG/SEG. Their results are published online in the April 3, 2014 issue of JAMA Ophthalmology.

"We included a subset of 78,980 women and 41,221 men who were 40 years or older, free of glaucoma, had completed dietary questionnaires, and reported an eye examination during follow-up," said lead author Jae H. Kang, Sc.D., Channing Division of Network Medicine, Department of Medicine, BWH/HMS. "Incident cases of EG/SEG, totaling 339 were first identified with the questionnaires and were subsequently confirmed with medical records. Multivariable relative risks for EG/SEG were calculated in each cohort and then pooled with meta-analysis."

The results showed that vitamin B6 and B12 intake was not associated with EG/SEG risk in pooled analyses (P= .52 and P= .99 for linear trend, respectively). However, there was a trend of a reduced risk of EG/SEG with higher total folate intake, with relations being stronger for higher folate intake from supplements than from diet alone.

"Our conclusions are that higher folate intake is associated with a lower risk for EG/SEG, supporting a possible causal role of homocysteine in EG/SEG," said senior author Louis Pasquale, M.D., Glaucoma Service Director, Mass. Eye and Ear. "More work needs to be done but these are critical insights that may give us a better understanding of how EG progresses, which helps to bring us closer to developing interventions or treatments that prevent this blinding disease."


Story Source:

The above story is based on materials provided by Massachusetts Eye and Ear Infirmary. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jae H. Kang, Stephanie J. Loomis, Janey L. Wiggs, Walter C. Willett, Louis R. Pasquale. A Prospective Study of Folate, Vitamin B6, and Vitamin B12Intake in Relation to Exfoliation Glaucoma or Suspected Exfoliation Glaucoma. JAMA Ophthalmology, 2014; DOI: 10.1001/jamaophthalmol.2014.100

Cite This Page:

Massachusetts Eye and Ear Infirmary. "Higher total folate intake may be associated with lower risk of exfoliation glaucoma." ScienceDaily. ScienceDaily, 3 April 2014. <www.sciencedaily.com/releases/2014/04/140403212531.htm>.
Massachusetts Eye and Ear Infirmary. (2014, April 3). Higher total folate intake may be associated with lower risk of exfoliation glaucoma. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2014/04/140403212531.htm
Massachusetts Eye and Ear Infirmary. "Higher total folate intake may be associated with lower risk of exfoliation glaucoma." ScienceDaily. www.sciencedaily.com/releases/2014/04/140403212531.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins