Featured Research

from universities, journals, and other organizations

Unexpected results in cancer drug trial: Combination of cetuximab, chemo had negative results

Date:
April 8, 2014
Source:
University of Southampton
Summary:
A drug, used in combination with chemotherapy to treat advanced colorectal cancer, is not effective in some settings, and indeed may result in more rapid cancer progression, research has shown. The study evaluated whether the drug cetuximab and chemotherapy together worked better than chemotherapy alone as a treatment in addition to surgery for people with bowel cancer that had spread to the liver but could be surgically removed. The researchers found that adding cetuximab to chemotherapy did not help this group of people.

Research from the University of Southampton has shown a drug, used in combination with chemotherapy to treat advanced colorectal cancer, is not effective in some settings, and indeed may result in more rapid cancer progression.

The New EPOC study, published in The Lancet Oncology and funded by Cancer Research UK, evaluated whether the drug cetuximab and chemotherapy together worked better than chemotherapy alone as a treatment in addition to surgery for people with bowel cancer that had spread to the liver but could be surgically removed. In the trial patients either received chemotherapy on its own or chemotherapy combined with cetuximab. Patients received their specified treatment for 12 weeks. They then had surgery and followed by their specified treatment for another 12 weeks. Patients were then monitored via CT or MRI scans.

The researchers found that adding cetuximab to chemotherapy did not help this group of people. Analysis looked at how long people in each group were living without any sign of their cancer getting worse. They found this was on average 14.1 months in the group having chemotherapy and cetuximab compared to 20.5 months in the group having chemotherapy alone.

John Primrose, Professor of Surgery at the University of Southampton, comments: "These results were unexpected. Cetuximab is already approved by NICE alongside chemotherapy for people who had bowel cancer that had spread to the liver if the oncologist and liver surgeon thought this would enable the patient to have a liver operation. The cetuximab and chemotherapy combination is also used successfully in patients whose disease cannot be operated on at all. Our trial tested it in people who had cancer spread to the liver who were suitable for surgery from the outset, a similar group, but for these patients it seems to have an adverse effect. More research is needed to understand this surprising result."

Professor Primrose, also a consultant surgeon at Southampton General Hospital, adds: "These are very important data and we would like to thank the patients and relatives of patients those who took part in this trial, as well as the many clinicians in the UK who participated. Our results demonstrate the importance of clinical trials to ensure patients with cancer receive the best of treatment for their condition."


Story Source:

The above story is based on materials provided by University of Southampton. Note: Materials may be edited for content and length.


Journal Reference:

  1. John Primrose, Stephen Falk, Meg Finch-Jones, Juan Valle, Derek O'Reilly, Ajith Siriwardena, Joanne Hornbuckle, Mark Peterson, Myrddin Rees, Tim Iveson, Tamas Hickish, Rachel Butler, Louise Stanton, Elizabeth Dixon, Louisa Little, Megan Bowers, Siân Pugh, O James Garden, David Cunningham, Tim Maughan, John Bridgewater. Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial. The Lancet Oncology, 2014; DOI: 10.1016/S1470-2045(14)70105-6

Cite This Page:

University of Southampton. "Unexpected results in cancer drug trial: Combination of cetuximab, chemo had negative results." ScienceDaily. ScienceDaily, 8 April 2014. <www.sciencedaily.com/releases/2014/04/140408111536.htm>.
University of Southampton. (2014, April 8). Unexpected results in cancer drug trial: Combination of cetuximab, chemo had negative results. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2014/04/140408111536.htm
University of Southampton. "Unexpected results in cancer drug trial: Combination of cetuximab, chemo had negative results." ScienceDaily. www.sciencedaily.com/releases/2014/04/140408111536.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) — Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) — Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins