Featured Research

from universities, journals, and other organizations

Dosage, timing may improve effectiveness of PI3K-inhibitors in breast cancer

Date:
April 9, 2014
Source:
Norris Cotton Cancer Center/Dartmouth-Hitchcock Medical Center
Summary:
Manipulation of drug dosage and schedules may improve anti-tumor effects of PI3K-inhibitors to target breast cancer tumors, research shows. These findings have implications for the optimal strategy to use such drugs in patients, and lay the groundwork for future development of anti-cancer therapeutics.

Researchers from the Geisel School of Medicine at Dartmouth will present a scientific poster at the American Association of Cancer Researchers conference in San Diego, CA. Their study suggests that manipulation of drug dosage and schedules may improve anti-tumor effects of PI3K-inhibitors to target breast cancer tumors. These findings have implications for the optimal strategy to use such drugs in patients, and lay the groundwork for future development of anti-cancer therapeutics.

Sixty-five percent of all breast cancers are estrogen receptor positive (ER+), with tumors that can stop growing or die when treated with drugs that block estrogen signaling. Eighty percent of these ER+ breast cancers have mutations on the PI3K pathway, which regulates cell growth. Drugs that target the PI3K pathway have shown promise for the treatment of anti-estrogen-resistant breast cancers in early clinical trials.

The Dartmouth researchers noted that in clinical studies, novel drugs are often delivered in escalating doses until toxicities are observed in patients; this approach doesn't provide information on target inhibition in tumors. Current PI3K inhibitor treatment regimens incompletely and temporarily inhibit the pathway in cancers, and are often accompanied by adverse effects in patients.

"We wanted to see if short-term, complete blocking of PI3K would have a greater impact on tumors, and also reduce the adverse effects," said Todd Miller, principal investigator on the study and assistant professor of Pharmacology and Toxicology at Geisel. "Our findings indicate that optimization of rational drug doses and schedules early in the clinical development process may improve anti-tumor effects in larger, later-phase trials."

The study suggests that short-term, complete inhibition of PI3K would have a greater anti-tumor effect than chronic, partial inhibition. The researchers will build on this study to test the anti-tumor efficacy of different treatment regimens of anti-estrogen and PI3K inhibition in different models of ER+/HER2- breast cancer.


Story Source:

The above story is based on materials provided by Norris Cotton Cancer Center/Dartmouth-Hitchcock Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Norris Cotton Cancer Center/Dartmouth-Hitchcock Medical Center. "Dosage, timing may improve effectiveness of PI3K-inhibitors in breast cancer." ScienceDaily. ScienceDaily, 9 April 2014. <www.sciencedaily.com/releases/2014/04/140409134316.htm>.
Norris Cotton Cancer Center/Dartmouth-Hitchcock Medical Center. (2014, April 9). Dosage, timing may improve effectiveness of PI3K-inhibitors in breast cancer. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2014/04/140409134316.htm
Norris Cotton Cancer Center/Dartmouth-Hitchcock Medical Center. "Dosage, timing may improve effectiveness of PI3K-inhibitors in breast cancer." ScienceDaily. www.sciencedaily.com/releases/2014/04/140409134316.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins