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Hepatitis C treatment cures over 90 percent of patients who also have cirrhosis

Date:
April 12, 2014
Source:
University of Texas Health Science Center at San Antonio
Summary:
Twelve weeks of an investigational oral therapy cured hepatitis C infection in more than 90 percent of patients with liver cirrhosis and was well tolerated by these patients, according to a new study.

Twelve weeks of an investigational oral therapy cured hepatitis C infection in more than 90 percent of patients with liver cirrhosis and was well tolerated by these patients.
Credit: Coloures-Pic / Fotolia

Twelve weeks of an investigational oral therapy cured hepatitis C infection in more than 90 percent of patients with liver cirrhosis and was well tolerated by these patients, according to an international study that included researchers from UT Medicine San Antonio and the Texas Liver Institute. Historically, hepatitis C cure rates in patients with cirrhosis (liver scarring) have been lower than 50 percent and the treatment was not safe for many of these patients.

Hepatitis C virus is the No. 1 driver of cirrhosis, liver transplants and liver cancer in the United States, noted Fred Poordad, M.D., lead author on the study, which was released Saturday by The New England Journal of Medicine in conjunction with Dr. Poordad's presentation of the data at the International Liver Congress in London. UT Medicine is the clinical practice of the School of Medicine at The University of Texas Health Science Center at San Antonio, where Dr. Poordad is a professor of medicine. He is vice president of the Texas Liver Institute in San Antonio.

Interferon previously was the only agent to show effectiveness against hepatitis C, but patients often relapsed and the therapy caused multiple side effects. The new regimen is interferon-free and consists of several agents -- ABT-450/ritonavir, ombitasvir, dasabuvir and ribavirin. Twelve weeks after the last dose, no hepatitis C virus was detected in the bloodstream of 91.8 percent of patients who took the pills for 12 weeks. Among patients treated for 24 weeks, 95.9 percent were virus-free 12 weeks after the end of therapy.

"These are out-of-the-ballpark response rates, not on the same planet as interferon," Dr. Poordad said. "The reason this study is so profound is because interferon is not tolerated nor is it safe in many people with cirrhosis. Many of the patients with cirrhosis in this study were not even eligible to be treated with interferon."

One of those patients was retired San Antonio anesthesiologist Sergio Buentello, M.D. Diagnosed with hepatitis C infection 11 years ago, Dr. Buentello had treatment with side effects and no cure eight years ago. "My viral count came down, but never to zero," he said.

When Eric Lawitz, M.D., of the Texas Liver Institute told him of the possibility of treatment with the new therapy, Dr. Buentello said he was skeptical. But as for so many others, the therapy worked.

"I feel very lucky to be living in this time, because I was almost resigned to the idea that I could never be cured," Dr. Buentello said.

The study examined outcomes in 380 patients at 78 sites, including hospitals and centers in Spain, Germany, England, Canada and the U.S. The biopharmaceutical company AbbVie provided support.

Investigators are cataloging patient blood samples for three years after therapy and so far have noticed no long-term, late relapses, Dr. Poordad said.

"Patients with advanced liver disease can now be cured of their hepatitis with a very well-tolerated and short regimen," he said.

The combination medication regimen is expected to be on the market as early as the end of 2014 or very early 2015.


Story Source:

The above story is based on materials provided by University of Texas Health Science Center at San Antonio. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fred Poordad, Christophe Hezode, Roger Trinh, Kris V. Kowdley, Stefan Zeuzem, Kosh Agarwal, Mitchell L. Shiffman, Heiner Wedemeyer, Thomas Berg, Eric M. Yoshida, Xavier Forns, Sandra S. Lovell, Barbara Da Silva-Tillmann, Christine A. Collins, Andrew L. Campbell, Thomas Podsadecki, Barry Bernstein. ABT-450/r–Ombitasvir and Dasabuvir with Ribavirin for Hepatitis C with Cirrhosis. New England Journal of Medicine, 2014; 140411220115009 DOI: 10.1056/NEJMoa1402869

Cite This Page:

University of Texas Health Science Center at San Antonio. "Hepatitis C treatment cures over 90 percent of patients who also have cirrhosis." ScienceDaily. ScienceDaily, 12 April 2014. <www.sciencedaily.com/releases/2014/04/140412093400.htm>.
University of Texas Health Science Center at San Antonio. (2014, April 12). Hepatitis C treatment cures over 90 percent of patients who also have cirrhosis. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2014/04/140412093400.htm
University of Texas Health Science Center at San Antonio. "Hepatitis C treatment cures over 90 percent of patients who also have cirrhosis." ScienceDaily. www.sciencedaily.com/releases/2014/04/140412093400.htm (accessed October 22, 2014).

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