Featured Research

from universities, journals, and other organizations

Outcome of stroke worse for people with infection

Date:
April 15, 2014
Source:
Manchester University
Summary:
Infection is bad news for all of us - but it can be really serious to people who have had a stroke. Evidence is mounting that infection makes things much worse after a stroke. The researchers show that rodents with pneumonia fared worse after having a stroke than those without the bacterial infection. This study builds on previous research demonstrating that an anti-inflammatory drug, called 'interleukin-1 receptor antagonist', could dramatically limit the amount of brain damage in experimental stroke.

Infection is bad news for all of us -- but it can be really serious to people who have had a stroke. Evidence is mounting that infection makes things much worse after a stroke.

Related Articles


A team of scientists at the University of Manchester has now found a key to why and how infection is such a bad thing for stroke sufferers.

In the research published today in the medical journal Annals of Neurology, the researchers show that rodents with pneumonia fared worse after having a stroke than those without the bacterial infection.

When people get an infection their natural defenses -- the immune system -- kicks in and produces responses to try to remove the infectious agent. This allows the body to return to normal. But the body's own natural defences can also be harmful.

This study showed how infection worsens the damage caused by a stroke, but more importantly showed how. The researchers identified particular blood cells called platelets, which normally help to stop bleeding, and a molecule that normally helps people to fight infection as the key culprits in making the effects of a stroke even more devastating.

Over the last 20 years scientists from The University of Manchester have been investigating how to reduce damage to the brain following a stroke. In doing so they hope to be able to lessen the impact that stroke has on patients. The team is jointly led by the University's President, Professor Dame Nancy Rothwell and Professor Stuart Allan.

Professor Allan said: "The results of this new study strongly suggest that patients with stroke, especially if they have preceding infections, could benefit substantially from anti-inflammatory therapies."

This study builds on previous research demonstrating that an anti-inflammatory drug, called 'interleukin-1 receptor antagonist', could dramatically limit the amount of brain damage in experimental stroke. This work has led to the drug being tested in stroke patients.

Professor Allan concluded: "Our latest findings give further support to the potential beneficial effect of 'interleukin-1 receptor antagonist' for stroke, even in those patients who might have preceding infection. A clinical trial of interleukin-1 receptor antagonist is soon to complete in patients with bleeding in the brain and is starting soon in stroke."


Story Source:

The above story is based on materials provided by Manchester University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Αdαm Dιnes, Jesus M. Pradillo, Caroline Drake, Andrew Sharp, Peter Warn, Katie N. Murray, Bazaz Rohit, David H. Dockrell, Janet Chamberlain, Helen Casbolt, Sheila Francis, Bernadett Martinecz, Bernhard Nieswandt, Nancy J. Rothwell, Stuart M. Allan. Streptococcus pneumoniaeworsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα. Annals of Neurology, 2014; DOI: 10.1002/ana.24146

Cite This Page:

Manchester University. "Outcome of stroke worse for people with infection." ScienceDaily. ScienceDaily, 15 April 2014. <www.sciencedaily.com/releases/2014/04/140415084150.htm>.
Manchester University. (2014, April 15). Outcome of stroke worse for people with infection. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2014/04/140415084150.htm
Manchester University. "Outcome of stroke worse for people with infection." ScienceDaily. www.sciencedaily.com/releases/2014/04/140415084150.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) — While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com
Smartphone Use Changing Our Brain and Thumb Interaction, Say Researchers

Smartphone Use Changing Our Brain and Thumb Interaction, Say Researchers

Reuters - Innovations Video Online (Mar. 25, 2015) — European researchers say our smartphone use offers scientists an ideal testing ground for human brain plasticity. Dr Ako Ghosh&apos;s team discovered that the brains and thumbs of smartphone users interact differently from those who use old-fashioned handsets. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Many Don't Know They Have Alzheimer's, But Their Doctors Do

Many Don't Know They Have Alzheimer's, But Their Doctors Do

Newsy (Mar. 24, 2015) — According to a new study by the Alzheimer&apos;s Association, more than half of those who have the degenerative brain disease aren&apos;t told by their doctors. Video provided by Newsy
Powered by NewsLook.com
A Quick 45-Minute Nap Can Improve Your Memory

A Quick 45-Minute Nap Can Improve Your Memory

Newsy (Mar. 23, 2015) — Researchers found those who napped for 45 minutes to an hour before being tested on information recalled it five times better than those who didn&apos;t. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins