Featured Research

from universities, journals, and other organizations

Imaging gives clearer picture of cancer drugs' chances of success

Date:
April 28, 2014
Source:
University of Edinburgh
Summary:
The quest for new cancer treatments could be revolutionized by advances in technology that can visualize living cells and tissues, scientists claim. Leading edge imaging techniques will make it easier to identify which are the most promising new drugs to take forward for patient testing, a review of the technology suggests.

The quest for new cancer treatments could be revolutionized by advances in technology that can visualize living cells and tissues, scientists claim.

Leading edge imaging techniques will make it easier to identify which are the most promising new drugs to take forward for patient testing, a review of the technology suggests.

Applying such techniques early in the drug discovery process could improve the success rate of new medicines by helping to rule out drugs that are unlikely to work.

Researchers at the University of Edinburgh are leading the way in using biological imaging to make the development of new cancer treatments more efficient.

Recent advances mean that scientists can now check how experimental drugs are working inside living cells and in real time.

Using automated microscopes to track fluorescent dyes, researchers can rapidly test thousands of potential drugs in different cancer cell types to find the most promising new treatments.

This pioneering approach -- known as phenotypic drug discovery -- monitors the effect of a trial drug on the disease as a whole rather than its impact on an individual target protein, which has been the approach until now.

Writing in the journal Nature Reviews Cancer, scientists argue that the new technologies will help to better predict how a drug will work in real life, not just in the test tube.

Currently, just five per cent of drugs tested in clinical trials are approved as therapies for patients. Often drugs do not work in a person as they do in an artificial environment. Sometimes treatments have unexpected side effects that are only picked up in the later stages of the development process.

Report author Dr Neil Carragher, of the Edinburgh Cancer Research UK Centre at the University of Edinburgh, said: "The drug discovery process is hugely expensive and inefficient. In Edinburgh we are leading the way in using biological imaging to streamline the process, allowing us to better select drug candidates with the lowest risk of side effects and the best chances of success in treating patients."


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. James R. W. Conway, Neil O. Carragher, Paul Timpson. Developments in preclinical cancer imaging: innovating the discovery of therapeutics. Nature Reviews Cancer, 2014; 14 (5): 314 DOI: 10.1038/nrc3724

Cite This Page:

University of Edinburgh. "Imaging gives clearer picture of cancer drugs' chances of success." ScienceDaily. ScienceDaily, 28 April 2014. <www.sciencedaily.com/releases/2014/04/140428121218.htm>.
University of Edinburgh. (2014, April 28). Imaging gives clearer picture of cancer drugs' chances of success. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2014/04/140428121218.htm
University of Edinburgh. "Imaging gives clearer picture of cancer drugs' chances of success." ScienceDaily. www.sciencedaily.com/releases/2014/04/140428121218.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins